Results 221 to 230 of about 148,871 (301)

Multiple‐Dose Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Subcutaneous Rusfertide, a Hepcidin Mimetic, in Healthy Subjects

Clinical Pharmacology in Drug Development, Volume 14, Issue 4, Page 311-323, April 2025.
Abstract Rusfertide, a peptide hepcidin mimetic, has shown efficacy in polycythemia vera. This trial investigated the multiple‐dose pharmacokinetics, pharmacodynamics, and safety of once‐weekly rusfertide 60 mg for 5 weeks in healthy subjects. Subjects were randomized to subcutaneous injection in the abdomen, upper arm, or thigh. Eighteen subjects were
Nishit B. Modi, Phillip Dinh, Ifode Ajari   +2 more
wiley   +1 more source

Investigation of Extracted Plasma Cell-Free DNA as a Biomarker in Foals with Sepsis. [PDF]

Vet Sci
Hobbs KJ, Cooper BL, Dembek K, Sheats MK.   +3 more
europepmc   +1 more source

Transparency, Resiliency, and Sustainable Supply Chain Network Design by Considering New Technology

Engineering Reports, Volume 7, Issue 4, April 2025.
This research proposes a new Supply Chain Network Design (SCND) model using emerging technologies. It aims to reduce costs while improving sustainability, flexibility, and transparency. A probabilistic optimization approach is employed, resulting in a 0.1% cost reduction.
Mansour Bazregar, Seyed Ali Reza Derakhshan, Nowrouz Nuorollahzadeh   +2 more
wiley   +1 more source

From quantum communication fundamentals to decoherence mitigation strategies: Addressing global quantum network challenges and projected applications. [PDF]

Heliyon
Khan MA, Ghafoor S, Zaidi SMH, Khan H, Ahmad A.   +4 more
europepmc   +1 more source

Prerequisites for Clinical Implementation of Whole‐Heart 4D‐Flow MRI: A Delphi Analysis

Journal of Magnetic Resonance Imaging, Volume 61, Issue 4, Page 1618-1628, April 2025.
Whole‐heart 4D‐flow MRI is a valuable tool for advanced visualization and quantification of blood flow in cardiovascular imaging. Despite advantages over 2D‐phase‐contrast flow, clinical implementation remains only partially exploited due to many hurdles in all steps, from image acquisition, reconstruction, postprocessing and analysis, clinical ...
Joost van Schuppen, Annelies E. van der Hulst, J. Michiel den Harder, Lukas M Gottwald, Raschel D. van Luijk, Josien C. van den Noort, Jules L. Nelissen, Casper F. Coerkamp, S. Matthijs Boekholdt, Paul F.C. Groot, Aart Nederveen, Pim van Ooij, R. Nils Planken, Delphi Panel Members   +13 more
wiley   +1 more source

Using Synthetic Health Care Data to Leverage Large Language Models for Named Entity Recognition: Development and Validation Study.

J Med Internet Res
Šuvalov H, Lepson M, Kukk V, Malk M, Ilves N, Kuulmets HA, Kolde R.   +6 more
europepmc   +1 more source

Is the threatened land crab Cardisoma guanhumi conquering human-dominated systems? [PDF]

Ecol Evol
Riascos JM, Obonaga LD, Ramos J.
europepmc   +1 more source

Targeting MDA‐MB‐231 Cancer Stem Cells With Temsirolimus in 3D Collagen/PGA/Na2SiO3‐Based Bone Model

Macromolecular Materials and Engineering, Volume 310, Issue 4, April 2025.
The efficacy of the mTORC1 inhibitor temsirolimus is assessed on CD44+/CD24‐ CSCs from MDA‐MB‐231, using a 3D bone‐like model with a PLA scaffold. Osteogenic differentiation of BM‐MSCs and CSC invasion are induced. After applying IC50 = 5 µM for 6 hours, mTOR protein levels are evaluated, stemness, epthelial‐mesenchymal transition (EMT), and drug ...
Özlem Altundag‐Erdogan, Hayrullah Çetinkaya, Mustafa Özgür Öteyaka, Betül Çelebi‐Saltik   +3 more
wiley   +1 more source

Harnessing ChatGPT for Thematic Analysis: Are We Ready?

J Med Internet Res
Lee VV, van der Lubbe SCC, Goh LH, Valderas JM.   +3 more
europepmc   +1 more source

PanKB: An interactive microbial pangenome knowledgebase for research, biotechnological innovation, and knowledge mining. [PDF]

Nucleic Acids Res
Sun B, Pashkova L, Pieters PA, Harke AS, Mohite OS, Santos A, Zielinski DC, Palsson BO, Phaneuf PV.   +8 more
europepmc   +1 more source