Results 251 to 260 of about 148,871 (301)

Identifying psychosocial and contextual markers considered by physicians to personalize care. [PDF]

BMC Med
Domenach P, Krause KR, Malmartel A, Ravaud P, Tran VT.   +4 more
europepmc   +1 more source

Imeglimin, unlike metformin, does not perturb differentiation of human induced pluripotent stem cells towards pancreatic β‐like cells and rather enhances gain in β cell identity gene sets

Journal of Diabetes Investigation, Volume 16, Issue 4, Page 584-597, April 2025.
Metformin is used in some countries as treatment for hyperglycemia in pregnancy (HIP), and beneficially improves maternal glucose metabolism and reduces perinatal complications, although metformin could impede pancreatic β cell development via impaired mitochondrial function.
Tasuku Imada, Shugo Sasaki, Hiroki Yamaguchi, Ayaka Ueda, Dan Kawamori, Naoto Katakami, Iichiro Shimomura   +6 more
wiley   +1 more source

Evaluating ChatGPT, Gemini and other Large Language Models (LLMs) in orthopaedic diagnostics: A prospective clinical study. [PDF]

Comput Struct Biotechnol J
Pagano S, Strumolo L, Michalk K, Schiegl J, Pulido LC, Reinhard J, Maderbacher G, Renkawitz T, Schuster M.   +8 more
europepmc   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Can large language models predict antimicrobial peptide activity and toxicity? [PDF]

RSC Med Chem
Orsi M, Reymond JL.
europepmc   +1 more source

A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum

Molecular Microbiology, Volume 123, Issue 4, Page 330-343, April 2025.
In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Nina Küster, Lena Roling, Ardin Ouayoue, Katharina Steeg, Jude M. Przyborski   +4 more
wiley   +1 more source

Transformer-based approach for symptom recognition and multilingual linking. [PDF]

Database (Oxford)
Vassileva S, Grazhdanski G, Koychev I, Boytcheva S.   +3 more
europepmc   +1 more source

Knocking out the carboxyltransferase interactor 1 (CTI1) in Chlamydomonas boosted oil content by fivefold without affecting cell growth

Plant Biotechnology Journal, Volume 23, Issue 4, Page 1230-1242, April 2025.
Summary The first step in chloroplast de novo fatty acid synthesis is catalysed by acetyl‐CoA carboxylase (ACCase). As the rate‐limiting step for this pathway, ACCase is subject to both positive and negative regulation. In this study, we identify a Chlamydomonas homologue of the plant carboxyltransferase interactor 1 (CrCTI1) and show that this protein
Zhongze Li, Minjae Kim, Jose Roberto da Silva Nascimento, Bertrand Legeret, Gabriel Lemes Jorge, Marie Bertrand, Fred Beisson, Jay J. Thelen, Yonghua Li‐Beisson   +8 more
wiley   +1 more source

Evaluating and addressing demographic disparities in medical large language models: a systematic review. [PDF]

Int J Equity Health
Omar M, Sorin V, Agbareia R, Apakama DU, Soroush A, Sakhuja A, Freeman R, Horowitz CR, Richardson LD, Nadkarni GN, Klang E.   +10 more
europepmc   +1 more source

Repurposing Waste Chemicals for Sustainable and Durable Molecular Data Storage. [PDF]

ACS Omega
Gumus S, Biechele-Speziale D, Manz KE, Pennell KD, Rubenstein BM, Rosenstein JK.   +5 more
europepmc   +1 more source