Results 181 to 190 of about 22,376 (246)

Eight coding-complete genomes of human metapneumovirus recovered by virus metagenomics in coastal Kenya, 2021-2024. [PDF]

Microbiol Resour Announc
Mwasya SK, Okanda D, Odoyo S, Katama EN, Lewa C, Lambisia AW, Githinji G, Agoti CN.   +7 more
europepmc   +1 more source

Inhibiting Glutaminase Reverses Senescence‐Associated Mitochondrial Dysfunction and Skeletal Muscle Decline

Aging Cell, Volume 25, Issue 10, October 2026.
Pharmacological inhibition of glutaminase with drug CB‐839 restores mitochondrial function in senescent myoblasts and enhances muscle strength and endurance in progeria mice. ABSTRACT Age‐associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction.
Hamsa Vardini Senthil Kumar, Debanik Choudhury, Pedro Lei, Pihu Mehrotra, Shahryar Shahini, Sydney Swedick, John Toftegaard, Stelios T. Andreadis   +7 more
wiley   +1 more source

Classifying Patient Complaints Using Artificial Intelligence-Powered Large Language Models: Cross-Sectional Study. [PDF]

J Med Internet Res
Koh SWC, Wong ERN, Tan JCM, van der Lubbe SCC, Goh JC, Ching ESY, Chia IWY, Low SH, Ang PY, Quek Q, Motani M, Valderas JM.   +11 more
europepmc   +1 more source

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

Aging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng, Xiaozhu Zeng, Jing Guo, Lihong Li, Shirui Zou, Nan Liu, Shuai He, Lanzhen Yan, Qiong Wang, Yongjie Zhu, Ben Wang, Dong Yang, Longbao Lv, Xudong Zhao   +13 more
wiley   +1 more source

Utilisation of Machine Learning Approaches Improves RNA-Seq Transcriptome Analyses in Alzheimer's Disease Brain. [PDF]

J Mol Neurosci
Cheng Y, Santucci K, Gao Y, Takenaka K, Lindner G, Xu SM, Janitz M.   +6 more
europepmc   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Challenges of using generative AI for patient education in chronic heart failure: an evaluation of content quality, readability, and actionability in cross-platform LLM-generated texts. [PDF]

Front Public Health
Wang Z, Li X, Ma C, Zhang Z.
europepmc   +1 more source

Application of Multi‐Method Dating for Understanding the Gravettian North of Moravia, Central Europe

Archaeometry, Volume 68, Issue 5, Page 1050-1061, October 2026.
ABSTRACT This article presents the results of integrating three methods to assess the age of the Upper Palaeolithic site of Pietraszyn 11 (SW Poland), close to the Moravian Gate. Sediment chronology determined using optically stimulated luminescence produced promising, yet ambiguous results (51.0 ± 3.7 to 20.3 ± 0.7 ka).
A. Wiśniewski, B. Bujalska, D. Popović, M. Baca, K. Zarzecka‐Szubińska, A. Lemanik, M. Hein, S. Talamo, P. Moska, H. Fewlass, D. Tokarz, Z. Jary, B. Przybylski, D. Bobak, M. Połtowicz‐Bobak, K. Wertz, A. Nadachowski   +16 more
wiley   +1 more source

Spatial Total RNA Sequencing of Formalin-Fixed Paraffin-Embedded Tissue by spRandom-seq. [PDF]

Small
Liao Y, Chen J, Zhang S, Chen J, Lyu Y, Zhu B, Chen H, Zhu Y, Dong L, Liang Q, Liu J, Xu Z, Chen YS, Wang Y.   +13 more
europepmc   +1 more source

Inducible tomato defences persist in detached leaves, despite differential plant variety and gene‐dependent expression

Ecological Entomology, Volume 51, Issue 5, Page 866-874, October 2026.
Short‐ and long‐term expression of PPO‐D, PI‐IIc and PR‐1a were assessed in intact plants and detached tomato leaves of two varieties infested with Tetranhycus urticae. Tomato defences were induced in both intact and detached leaves, but the induction levels varied with plant variety and gene assessed.
Mariya Kozak, Diogo P. Godinho, Eren Yayla, Juan Adánez, Inês Fragata, Sara Magalhães, Leonor R. Rodrigues   +6 more
wiley   +1 more source