Results 161 to 170 of about 28,958 (312)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Turbulent Mixing in the Upper Arctic Ocean Energized by Interactions of Tidally‐Forced Waves With Mesoscale Shear

Geophysical Research Letters
High‐resolution observations in Fram Strait reveal complex interactions across scales, highlighting the role of internal waves in enhancing mixing within the meltwater halocline.
S. F. Reifenberg, I. Fer
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

DNS of aerosol evolution in a turbulent mixing layer

, 2013
The complex interaction of turbulent mixing and aerosol growth processes in a canonical turbulent flow configuration is investigated by means of direct numerical simulation.
Zhou, Kun, Attili, Antonio, Alshaarawi, Amjad, Bisetti, Fabrizio   +3 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A Methodological Approach to Process Intensification [PDF]

, 2000
A methodological approach to process intensification (PI) has been developed to aid in the design of intensified chemical processes. Current process development procedures fail to consider if, and how, a chemical process can be intensified, resulting ...
Wood, Mark D.
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Time-Resolved Measurements of Turbulent Mixing in Shock-Driven Variable-Density Flows. [PDF]

Sci Rep, 2019
Carter J, Pathikonda G, Jiang N, Felver JJ, Roy S, Ranjan D.   +5 more
europepmc   +1 more source

Observational and Numerical Methods for Quantifying and Modeling of Turbulence in a Stratified Reservoir

Journal of Applied Fluid Mechanics, 2016
The interplay between stratification and shear in lakes controls the vertical mixing, which is the most important mechanism affecting the transport of heat, salt, momentum and suspended and dissolved substances.
Sebnem Elci, Huseyin Burak Ekmekçi
doaj