Results 111 to 120 of about 275,295 (247)

Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p

eLife
Understanding cortical circuit development requires tracking neuronal activity across days in the growing brain. While in vivo calcium imaging now enables such longitudinal studies, automated tools for reliably tracking large populations of neurons ...
Jure Majnik, Manon Mantez, Sofia Zangila, Stéphane Bugeon, Léo Guignard, Jean-Claude Platel, Rosa Cossart   +6 more
doaj   +1 more source

AI-derived prognostic biomarkers from melanoma whole slide image segmentation: an initial discovery and assessment. [PDF]

J Pathol Clin Res
Abstract The current melanoma staging system predicts 74% of the variance in survival, with prognostic biomarkers subject to high levels of inter‐observer variation. This work assesses whether a previously developed convolutional neural network (CNN) for invasive melanoma segmentation in whole slide images (WSIs) may reveal new insights into melanoma ...
Clarke EL, Magee D, Newton-Bishop J, Saldanha G, Merchant W, Hall M, Insall R, Maher NG, Scolyer RA, Farnworth G, Ali A, Bamford M, Sticova E, Kujal P, O'Shea S, Treanor D.   +15 more
europepmc   +2 more sources

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Induction of host genes by nested genes during C. elegans development

iScience
Summary: Embryonic development relies on tightly controlled gene expression. In this study, we analyzed the transcriptional effect during C. elegans development of a striking genomic topology, the opposite nested configuration, where a gene is located in
Fabien Soulavie, Carole Couillault, Matéo Melki, Khulganaa Buyannemekh, Antoine Barrière, Paul Villoutreix, Vincent Bertrand   +6 more
doaj   +1 more source

Variance Matrix Priors for Dirichlet Process Mixture Models With Gaussian Kernels

International Statistical Review, EarlyView.
Summary Bayesian mixture modelling is widely used for density estimation and clustering. The Dirichlet process mixture model (DPMM) is the most popular Bayesian non‐parametric mixture modelling approach. In this manuscript, we study the choice of prior for the variance or precision matrix when Gaussian kernels are adopted.
Wei Jing, Michail Papathomas, Silvia Liverani   +2 more
wiley   +1 more source

Do the biological characteristics of trout (Salmo trutta) smolts influence their spring migration timing and maiden marine sojourn duration?

Journal of Fish Biology, EarlyView.
Abstract Anadromous salmonids migrate seaward to exploit feeding and growth opportunities in marine habitats, yet how smolt biological characteristics influence their marine migratory behavior remains poorly understood. This study used 9 years of trout (Salmo trutta) population monitoring data from 15,595 tagged age‐0+ parr, 1033 smolts detected ...
Jonathan P. Gillson, Robert E. Blackwell, Stephen D. Gregory, Jessica E. Marsh, Tea Bašić, Sophie A. M. Elliott, R. Andrew King, David L. Maxwell, William D. Riley, Jamie R. Stevens, Alan M. Walker, Rasmus B. Lauridsen   +11 more
wiley   +1 more source

Digital twins as self-models for intelligent structures

Scientific Reports
A self-model is an artificial intelligence that is able to create a continuously updated internal representation of itself. In this paper we use an agent-based architecture to create a ‘digital twin self-model’, using the example of a small-scale three ...
Xiaoxue Shen, David J. Wagg, Matthew Tipuric, Matthew S. Bonney   +3 more
doaj   +1 more source

First Description and Characterisation of Lactococcus garvieae Strains Causing Septicaemic Disease in Farmed Sea Bass (Dicentrarchus labrax; Linnaeus) in Spain

Journal of Fish Diseases, EarlyView.
ABSTRACT This study presents the first description and characterisation of Lactococcus garvieae isolated from diseased European sea bass (Dicentrarchus labrax) farmed in Spain. During autumn 2023, two fish farms were affected by infectious outbreaks causing moderate cumulative fish mortality (5%–10%). Diseased fish showed clinical signs of haemorrhagic
Belén Fouz, Evelyn Carballeda‐Carrasco, Javier Barriga‐Cuartero, Yolanda Torres‐Corral, Álvaro Robles, Carlos Zarza, Ysabel Santos   +6 more
wiley   +1 more source

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation

Nature Communications
During development cell deformations are spatially organized, however, how cellular mechanics is spatially controlled is unclear. Spatial control of cell identity often determines local cellular mechanics in a two-tiered mechanism.
Gayatri Mundhe, Valentin Dunsing-Eichenauer, Jean-Marc Philippe, Élise Da Silva, Claudio Collinet, Thomas Lecuit   +5 more
doaj   +1 more source

mimicINT: A workflow for microbe-host protein interaction inference [version 2; peer review: 2 approved]

F1000Research
Background The increasing incidence of emerging infectious diseases is posing serious global threats. Therefore, there is a clear need for developing computational methods that can assist and speed up experimental research to better characterize the ...
Andreas Zanzoni, Lilian Drets, Mégane Boujeant, Marceau Cristianini, Christine Brun, Aurélie Bergon, Lionel Spinelli, Kevin Maldonado, Sébastien A. Choteau   +8 more
doaj   +1 more source