Results 131 to 140 of about 244,398 (299)
ChildrenExternal apical root resorption in permanent teeth is a multifactorial process influenced by a variety of local and systemic factors. This report describes a case of multiple and severe apical root resorptions in a patient with Turner syndrome.
Joanna Laskowska +4 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil +7 more
wiley +1 more source
Glasgow Contributions to the Human Gene Mapping Project, 1959-1987 [PDF]
, 2015 No abstract ...
Ferguson-Smith, Malcolm
core
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
Health Inequalities and People with Learning Disabilities in the UK [PDF]
, 2011 This briefing paper will assist Primary, Acute and Specialist NHS Trusts in fulfilling their responsibilities. In this report we summarise the most recent evidence from the UK on the health status of people with learning disabilities and the determinants
Allerton, Lindsay +3 more
core +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
State-of-Science review: learning difficulties: SR-D4: Dyscalculia [PDF]
, 2008 Low numeracy skills in general and developmental dyscalculia (DD) in particular constitute a severe handicap. This review examines the causes and behavioural manifestations of numeracy deficits, their neuropsychological correlates and the limits to our
Butterworth, B.
core
Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source