Results 121 to 130 of about 2,629,242 (377)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Natural dye modification of polyethylene oxide: optical characterization and dielectric enhancement

Journal of Materials Science: Materials in Engineering
This study explores the optical properties of polyethylene oxide (PEO) modified with natural dye extracted from hollyhock (HH) flowers. This study is a green chemistry approach to reduce the optical band gap of PEO polymer.
Shujahadeen B. Aziz, Dana S. Muhammad, Sewara J. Mohammed, Daron Q. Muheddin, Shakhawan Al-Zangana, Ahang M. Hussein, Ary R. Murad, Govar H. Hamasalih, Samir M. Hamad, Dilshad Shaikhah   +9 more
doaj   +1 more source

Influence of Tool-Workpiece Interface on Surface Integrity after Turning

Communications, 2014
This paper deals with influence of flank wear on decomposition of cutting force in turning roll bearing steel. The decomposition is carried out to evaluate the components of cutting force in the tool-chip as well as tool-workpiece interface.
Jaroslav Dubec, Miroslav Neslusan, Anna Micietova, Maria Cillikova   +3 more
doaj   +1 more source

Turning the Corner on Mass Incarceration? [PDF]

, 2011
For the first time in forty years, the national incarceration rate is flattening out, even falling in state prisons. For the first time in three decades, the number of adults under any kind of correctional supervision—in prison or jail or on probation or
Cole, David
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Investigations of Surface Roughness and Temperatures in Vegetable Oil-based n-MQL Turning of AISI 4340 Steel [PDF]

Journal of Engineering, Project, and Production Management
Machining of hard materials has been difficult and expensive because of poor surface smoothness, early tool failures, etc. When used in machining hard materials, such as medium and high carbon, cast steels, Inconel, and other alloys, nanomaterials ...
VeeraBhadraRao Miriyala, Bhushan T. Patil, Vasim A. Shaikh, D.S.S. Sudhakar, Sujata Deshmukh   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Forecasting Metals Returns A Bayesian Decision Theoretic Approach [PDF]

Turning points in commodity returns are important for decisions of policy makers, commodity producers and consumers reliant on medium term outcomes.
David Halperin
core  

Exhibition Catalog for Blind Corners, Portals and Turning Points [PDF]

, 2011
This catalog features work from the exhibit Blind Corners, Portals and Turning Points by Ronald Mills de Pinyas. Blind Corners, Portals and Turning Points was presented by the Linfield Gallery and the Department of Art and Visual Culture at Linfield ...
Mills de Pinyas, Ronald, Winkenweder, Brian   +1 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source