Results 41 to 50 of about 372,160 (306)

EU geopolitical positioning in multipolar world and its impact on the strategic determination of the Republic of Serbia [PDF]

Војно дело, 2017
Diverse strategic interests of the Anglo-Saxon countries, Central Europe, Eurasia, the seaborne empires (thalassocracy) and the land forces (tellurocracy) have intertwined and confronted in Europe for centuries.
Vračar Milinko, Šaranović Jovanka
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

POLAND'S NATIONAL SECURITY POLICY IN A NEW REGIONAL SECURITY ENVIRONMENT. CASE STUDY: NATIONAL SECURITY STRATEGY OF POLAND (2014)

Torun International Studies, 2018
Military aggression conducted by Russia against Ukraine was a turning point on the scene of international relations, and, particularly, in Europe. The Russian aggression against Ukraine, completed by the illegal occupation and annexation of the Crimean ...
Anton Moldovan
doaj   +1 more source

Teach phenomenology the bomb: Starship Troopers, the technologized body, and humanitarian warfare [PDF]

, 2005
Paul Verhoeven's SF films are often concerned with how the future body will be reshaped as a technological device. Starship Troopers strangely departs from Verhoeven's own work, other SF films, and current directions in cultural theory by seeing the ...
Clements Jonathan, Crawford Hugh T, O'Hehir Andrew, Philip Leonard   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Is the Cold War finally getting hot in Turkey? The ‘Cold War turn’ in Turkish Studies

Cold War History
Turkey has been largely missing in the new global histories of theCold War. This review essay will argue that Turkish Studies failed tomake a proper contribution to Cold War history because of a para-digmatic fixation on the determinism of the early Kemalist state-formation.
Yenen, A.A., Örnek, C.
openaire   +2 more sources

Assessing and valorizing the values of Belgian reconstruction cityscapes today : revisiting Labo S’s engagement with Ypres and Heuvelland [PDF]

, 2018
Readily dismissed as inauthentic vieux-neuf, the centrally orchestrated architectural production during the Belgian reconstruction campaigns after the Great War faced a rather cold architecture historical reception in Belgium.
Liefooghe, Maarten
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source