Results 181 to 190 of about 497,491 (219)

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Evaluation of Nurses' Intent to Leave: Italian Translation, Cultural Adaptation, and Initial Psychometric Assessment of the Anticipated Turnover Scale. [PDF]

Nurs Open
Cignola S, Bembich S, Sanson G.
europepmc   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Thermodynamic screening of solid-gas CO₂ mineral carbonation: a provenance-traceable Gibbs-energy framework across 23 reactions. [PDF]

RSC Adv
Alturki AA.
europepmc   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Nanocluster‐Assisted OH Ligand Modification Optimizes Activity and Stability of Fe‐N‐C Catalysts

Advanced Science, EarlyView.
A nanocluster‐assisted ligand engineering stabilizes OH‐modified FeN4 active sites through strong electronic coupling between isolated Fe atoms and adjacent nanoclusters. This synergy optimizes oxygen‐intermediate adsorption, lowers ORR energy barriers, and breaks the conventional activity–stability trade‐off, enabling high ORR activity, exceptional ...
Xue Zhao, Junpeng Chen, Shice Wang, Zhao Yu, Jing Wang, Qiuming Peng, Ge Li   +6 more
wiley   +1 more source

Back to Basics: Uncovering Biomarkers of Bone Disease Risk in Kidney Failure. [PDF]

Kidney Int Rep
Gutiérrez OM.
europepmc   +1 more source

Association Between Glycemic Variability and Bone Turnover and the Sema3A Signaling Pathway in Postmenopausal Women with Type 2 Diabetes Mellitus. [PDF]

Metabolites
Bora BC, Erarslan S.
europepmc   +1 more source

Job satisfaction among Saudi and Non-Saudi critical care and emergency nurses: associations with psychological distress, turnover intention, and perceived retention strategies. [PDF]

BMC Nurs
Saleh ZT, Al-Za'areer MS, Elshatarat RA, Alasmari AA, Almagharbeh WT, Alshameri FA, Zaiton H, Allugmani AR, Aljuhani BH, Aloufi RS, Al-Sayaghi KM, Alsulami GS, Amoush AH, Ismail MS.   +13 more
europepmc   +1 more source