Results 51 to 60 of about 48,459 (262)
Advanced Science, EarlyView.This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
Continuité, canonicité et complétude dans Doctor Who
TV Series, 2014 This article explores the complex relation to continuity in the British show Doctor Who (BBC, 1963-1989, 2005-), by looking into its multi-auctoriality from a diachronic and then synchronic point of view, and by detailing a fictional world dispersed ...
Florent Favard
doaj +1 more source
Advanced Science, EarlyView.Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou +6 more
wiley +1 more source
« Reality is out there » : le néo-réalisme fantastique dans quelques épisodes de The X-Files
TV Series, 2012 From the series X-Files, what often stands out is the paranoid structure around which the continuity of the principal storyline is constructed — the conspiracy theory that structures, or at least provides unity, over the course of seasons, beyond the ...
Emmanuelle Delanoë-Brun
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Advanced Science, EarlyView.ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo +13 more
wiley +1 more source
Monstrueuse convergence ? Penny Dreadful, ou la littérature à l’épreuve de la transmédialité
TV Series, 2017 Although it was labelled a monster mash upon its release, Penny Dreadful (Showtime, 2014) offers a subtle combination of literature and film. Indeed, the series strangely blends Shakespeare with The Exorcist, Mary Shelley’s Frankenstein with The Phantom ...
Sébastien Lefait
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Advanced Science, EarlyView.This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li +7 more
wiley +1 more source
Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
Advanced Science, EarlyView.We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
TV Series, 2017 If today’s television landscape is ripe with Gothic or supernatural dramas (True Blood, Penny Dreadful, Supernatural), paranormal crime dramas (X-Files, Grimm) and, on children’s networks, animated or live-action sitcoms about monsters and ghouls trying ...
Dennis Tredy
doaj +1 more source