Results 41 to 50 of about 1,357 (168)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of Non Ionic Surfactant Addition to Cellulase Performance in High-Substrate-Loading-Hydrolysis of Palm Oil EFB and Water-Hyacinth

Indonesian Journal of Chemistry, 2013
Enzymatic hydrolysis with high substrate loading of palm oil (Elaeis guineensis) empty fruit bunch (EFB) and water-hyacinth (Eichhornia crassipes) were investigated as a prior part of ethanol production from lignocelluloses. Commercial surfactant Span 85
Teuku Beuna Bardant, Sudiyarmanto Sudiyarmanto, Haznan Abimanyu, Aisha Kania Hanum   +3 more
doaj   +1 more source

The influence of membrane composition on the release of polyphenols from liposomes [PDF]

Hemijska Industrija, 2015
Polyphenols are compound which are widely studied because of their antioxidative and potential therapeutic properties. Systems for the controlled release of drugs offer a number of benefits comparing with traditional forms of medicines and ...
Pravilović Radoslava N., Radunović Vesna S., Bošković-Vragolović Nevenka M., Bugarski Branko M., Pjanović Rada V.   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stability and Kinetic Study of Vitamin C containing Hydrogenated and Middle-Chain Triglyceride Coconut Oil-Based Double Emulsion

International Journal of Technology
Vitamin C or ascorbic acid, is an organic compound that is highly required by human since it acts as antioxidant, help increase metabolism, and improves the immune system. Vitamin C is easily oxidized and damaged during storage due to several external
Lanny Sapei, Emma Savitri, Ignasius Radix A.P. Jati, Rochmad Indrawanto, Hillary Emmanuella Darsono, Yenni Anggraeni, Cindy Sumampouw   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Design of Delivery Systems (Nanoemulsions and Biopolymer Nanoparticles) of Cloves Essential Oil: Preparation, Characterizations, Study the Release, and Antioxidant Activity

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: Clove oil has a wide range of therapeutic and pharmaceutical applications. It is also used in the manufacture of pesticides and antifungals, as well as many advantages.
Mariam Kadhim Taher, Israa Qusay Falih, Younus Jasim Abdullah   +2 more
doaj   +1 more source

Study of Lipase Producing Bacterial Strains from Oil Contaminated Soil

Journal of Basic and Applied Research in Biomedicine, 2022
Lipase producing bacterial strains were isolated from oil contaminated soils and grown on nutrient agar medium containing 1% (w/v) Tween-20. The isolate showing maximum activity was identified by following Berger’s manual.
Chitra Bhattacharya, Bhawana Pandey, Ashis Sarkar   +2 more
doaj