Results 21 to 30 of about 57 (57)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Can AI‐Mediated Informal Digital Learning of English Enhance Translation Performance? The Mediating Role of Growth Translation Mindset

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT Drawing on social cognitive theory, this study examined the role of growth translation mindset (GTM) in linking AI‐mediated informal digital learning of English (AI‐IDLE) to translation performance among Chinese EFL learners. Quantitative data were collected from 378 college students, followed by 12 semi‐structured interviews.
Jin Liu   +5 more
wiley   +1 more source

How Strategic Leaders Drive Firms in Ecosystems: Envisioning Value, Orchestrating Knowledge, and Shifting Roles

open access: yesJournal of Management Studies, EarlyView.
Abstract Research on business ecosystems has illuminated how ecosystems emerge, evolve, and transform, revealing ecosystem‐level dynamics and the central actors that orchestrate them. Yet, it is individual firms that continuously attempt to establish and shift the roles they play within ecosystems through the vision and choices of their strategic ...
Paolo Aversa   +3 more
wiley   +1 more source

Metabolic convergence on TOR signaling in the chestnut blight fungus and its regulation by host plant signals

open access: yesNew Phytologist, EarlyView.
Proposed model of metabolic convergence on the target of rapamycin (TOR) pathway in Cryphonectria parasitica. Twelve core genes involved in diverse metabolic pathways act as upstream regulators or downstream effectors of TOR kinase. Dysregulation of these genes mimics an inhibited TOR state, leading to restricted hyphal growth and enhanced trehalose ...
Yo‐Han Ko   +4 more
wiley   +1 more source

Engineered surface strategies to manage dental implant‐related infections

open access: yesPeriodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza   +7 more
wiley   +1 more source

Twelve‐Month Discontinuation of Contraceptive Methods: A Global Systematic Review and Meta‐Analysis

open access: yesStudies in Family Planning, EarlyView.
Abstract Monitoring contraceptive discontinuation is crucial to reduce unmet needs and unintended pregnancies while supporting person‐centered counseling. The objective is to summarize discontinuation rates by method type (long‐acting reversible contraceptive [LARC] or short‐acting reversible contraceptive [SARC]), type (abandonment or switching), and ...
Fernanda Gontijo Araújo   +3 more
wiley   +1 more source

Integrating Tummy Time Into Routine NICU Care: Healthcare Workers’ Perspectives on Long‐Term Implementation in India

open access: yesPhysiotherapy Research International, Volume 32, Issue 1, January 2027.
ABSTRACT Background and Purpose Prone positioning for play (‘Tummy Time’) is an evidence‐based recommendation that supports early sensory‐motor development during infancy. Infants who require neonatal intensive care face a heightened risk of motor developmental delays, underscoring the importance of early developmental care practices.
Amruta Chutke   +3 more
wiley   +1 more source

Oxidative Catalytic Depolymerization of Technical Lignins to Vanillin(Derivatives) Using Polyoxometalate Catalysts

open access: yesAdvanced Chemical Engineering, Volume 1, Issue 2, December 2026.
A nickel‐substituted polyoxometalate catalyst enables efficient lignin degradation into monoaromatic compounds in a methanol–water solution. ABSTRACT The transition from fossil‐based resources to renewable feedstocks is a cornerstone of industrial decarbonization.
Dorothea Voß   +4 more
wiley   +1 more source

Evidence‐based design guidelines for holistic scoring of student tasks: A systematic literature review

open access: yesReview of Education, Volume 14, Issue 3, December 2026.
Abstract Since holistic scoring leaves room for multiple solutions and creativity, it seems an efficient and effective way to evaluate student performance. However, in practice, there are different views of what holistic scoring entails, what matching instruments look like, and how they should be designed to reap the benefits and avoid the drawbacks ...
Anne Lohuis   +2 more
wiley   +1 more source

Primary school‐based interventions to support the psychosocial functioning of children with neurodevelopmental diagnoses: A systematic review and meta‐analysis

open access: yesReview of Education, Volume 14, Issue 3, December 2026.
Abstract Children with neurodevelopmental or mental health diagnoses often face barriers to their successful psychosocial functioning at school. This study aimed to systematically review the key characteristics and quality of primary school‐based interventions that evaluate psychosocial functioning and to conduct a meta‐analysis of the interventions ...
Katherine Spender   +5 more
wiley   +1 more source

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