Results 151 to 160 of about 2,631 (192)

Mechanisms of twin screw melt granulation

Journal of Drug Delivery Science and Technology, 2021
Abstract Twin screw melt granulation is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. Twin screw melt granulation has been rapidly gaining interest over recent years in the pharmaceutical industry.
Tongzhou Liu, Feng Zhang
exaly   +2 more sources

Twin screw wet granulation: Granule properties

Chemical Engineering Journal, 2010
Abstract Granulation is an important particle size enlargement process, used in many applications. Granulation has, for many years, been a batch process because of a greater knowledge base. However, the technique of using a twin screw granulator has been found to be very effective at granulating and is an attractive proposition for manufacturing ...
Ranjit M Dhenge   +2 more
exaly   +2 more sources

Twin screw granulation: Steps in granule growth

International Journal of Pharmaceutics, 2012
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied.
Ranjit M Dhenge   +2 more
exaly   +3 more sources

Twin screw granulation as a simple and efficient tool for continuous wet granulation

International Journal of Pharmaceutics, 2004
The modification of a twin screw extruder for continuous wet granulation was investigated. Modification of the extruder setup as well as the screw design allowed the continuous wet granulation of alpha-lactose monohydrate without the need of a wet sieving step.
A Vermeire, C Vervaet, J P Remon
exaly   +3 more sources

Granulation of increasingly hydrophobic formulations using a twin screw granulator

International Journal of Pharmaceutics, 2014
The application of twin screw granulation in the pharmaceutical industry has generated increasing interest due to its suitability for continuous processing. However, an understanding of the impact of formulation properties such as hydrophobicity on intermediate and finished product quality has not yet been established.
Gavin Reynolds, Agba D Salman
exaly   +3 more sources

Twin-screw melt granulation: Current progress and challenges

International Journal of Pharmaceutics, 2020
Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with ...
Tongzhou Liu, Feng Zhang, Feng Zhang
exaly   +3 more sources

Comparison of two twin-screw extruders for continuous granulation

European Journal of Pharmaceutics and Biopharmaceutics, 2009
A comparison was made between two twin-screw extruders (APV Baker and Leistritz Micro) used for continuous wet granulation. Both extruders had similar screw configurations, based on the length-to-diameter ratio of the screws, existing out of a conveying zone of 20 D, i.e. 20 times the screw diameter and a granulation zone of 4D.
Peter Kleinebudde, J P Remon
exaly   +3 more sources

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