Results 161 to 170 of about 2,631 (192)
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Twin screw wet granulation: Effects of properties of granulation liquid
Powder Technology, 2012Abstract The effect of the properties of the granulation liquid, i.e. viscosity (amount of binder) and surface tension on residence time, torque and granule properties such as size, shape, structure, strength and flowability was studied in a co-rotating twin screw granulator.
Ranjit M Dhenge +2 more
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A review of twin screw wet granulation mechanisms in relation to granule attributes
Drug Development and Industrial Pharmacy, 2021Due to the trend of continuous pharmaceutical manufacturing, twin screw wet granulation (TSWG), a continuous process, has gained increased research interest as a potential substitution of traditional batch granulation processes. Despite the complex nature of TSWG, its mechanisms have been gradually unveiled with the aid of innovative research ...
Yi, Zhang +3 more
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Twin screw wet granulation: Binder delivery
International Journal of Pharmaceutics, 2015The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh +4 more
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Twin screw granulation – review of current progress
Drug Development and Industrial Pharmacy, 2014Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but ...
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Continuous twin screw extrusion for the wet granulation of lactose
International Journal of Pharmaceutics, 2002The suitability of continuous twin screw extrusion for the wet granulation of alpha-lactose monohydrate was studied and compared with conventional high shear granulation. The influence of process parameters (screw speed and total input rate) and formulation variables (water and polyvinylpyrrolidone (PVP) concentration) on the properties of granules ...
E I, Keleb +3 more
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Influence of filler selection on twin screw foam granulation
Drug Development and Industrial Pharmacy, 2013The influence of filler selection in wet granulation was studied for the novel case where the binder is delivered as an unstable, semi-rigid aqueous foam to an extrusion process. The work primarily examined the impact of differing concentrations of microcrystalline cellulose (Avicel PH® 101) in a formulation with spray-dried α-lactose monohydrate ...
K E, Rocca +3 more
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Pharmaceutical Development and Technology, 2019
This study investigated an influence of granulation temperature during twin-screw granulation (TSG) on particle size distributions (PSDs). The influence of the granulation temperature on granule size distributions varied, depending on the liquid to solid (L/S) ratio, the kind of binders, the method of binder addition, and the filler material.
Akihiko, Ito, Peter, Kleinebudde
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This study investigated an influence of granulation temperature during twin-screw granulation (TSG) on particle size distributions (PSDs). The influence of the granulation temperature on granule size distributions varied, depending on the liquid to solid (L/S) ratio, the kind of binders, the method of binder addition, and the filler material.
Akihiko, Ito, Peter, Kleinebudde
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A study of foam granulation and wet granulation in a twin screw extruder
The Canadian Journal of Chemical Engineering, 2012AbstractThis research investigated a new technique known as foam granulation for the continuous manufacturing of pharmaceuticals by a twin screw extruder. Six grades of hypromellose were compared as binders in the trials, using two addition methods: foam injection by auxiliary side stuffer feeder and liquid injection directly into the extruder.
S. Weatherley +2 more
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Granulation rate processes in the kneading elements of a twin screw granulator
AIChE Journal, 2013To characterize the granulation rate processes in the kneading section of the twin screw granulator, separate experiments were conducted using exclusively conveying elements as the baseline in addition to different configurations of kneading elements. The configuration parameters examined were the length of the kneading section, the advance angle, and ...
A. S. El Hagrasy, J. D. Litster
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European Journal of Pharmaceutics and Biopharmaceutics, 2012
In this paper, Positron Emission Particle Tracking (PEPT) techniques are utilised to track the trajectory of single particles through the mixing and conveying zones of a Twin Screw Granulator (TSG). A TSG consisting of conveying zones and mixing zones is used in this study. The mixing zones are arranged with kneading discs at an angle of 30°, 60° or 90°
Kai T, Lee, Andy, Ingram, Neil A, Rowson
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In this paper, Positron Emission Particle Tracking (PEPT) techniques are utilised to track the trajectory of single particles through the mixing and conveying zones of a Twin Screw Granulator (TSG). A TSG consisting of conveying zones and mixing zones is used in this study. The mixing zones are arranged with kneading discs at an angle of 30°, 60° or 90°
Kai T, Lee, Andy, Ingram, Neil A, Rowson
openaire +2 more sources