Results 171 to 180 of about 2,631 (192)
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Heat assisted twin screw dry granulation
AIChE Journal, 2017A new “assisted” dry granulation method has been devised for the twin‐screw granulator. The method may be beneficial to drug preparation as it limits heat exposure to only one barrel zone, much shorter than melt granulation. Its mechanism was investigated using four placebo formulations, each containing a polymer binder with a glass transition ...
Y. Liu +3 more
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Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation
International Journal of Pharmaceutics, 2020Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation time varied).
Kristina E, Steffens +4 more
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International Journal of Pharmaceutics, 2020
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties.
Andrew Megarry +4 more
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Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties.
Andrew Megarry +4 more
openaire +2 more sources
Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
International Journal of PharmaceuticsTwin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive research conducted on the impact of screw geometry in melt compounding, there is not enough literature for TSMG.
Adwait Pradhan +7 more
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Continuous Twin-Screw Granulation Processing
2022Uttom Nandi, Tumpa Dey, Dennis Douroumis
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Wet Granulation in a Twin Screw Extruder
2018Master of Applied Science (MASc)
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Understanding Scalability In A Twin Screw Wet Granulation
2022Master of Applied Science (MASc)
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TWIN SCREW WET AND DRY GRANULATION
2017Twin screw granulation has gained wide interest by pharmaceutical manufacturing and the industry is still trying to expand its application. This thesis will further explore this technique and try to develop a new granulation strategy based on similar machinery setups.
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