Results 41 to 50 of about 547,720 (307)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Twin and sibling studies using health insurance data: the example of attention deficit/hyperactivity disorder (ADHD). [PDF]

PLoS ONE, 2013
BACKGROUND AND AIMS: Twin studies are used to assess the contribution of genetic factors to the aetiology of diseases. To show the feasibility of such research on the basis of health insurance data, we analysed twin and sibling data on the attention ...
Ingo Langner, Edeltraut Garbe, Tobias Banaschewski, Rafael T Mikolajczyk   +3 more
doaj   +1 more source

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population [PDF]

, 2015
Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD ...
Starr, J., D J Porteous, Hocking, L J, Porteous, D. J., Thomson, P A; id_orcid, Hocking, L. J., Davies, G., Medland, S E, S E Medland, Hocking, L.J., Wright, M.J., Porteous, D J, J Starr, Lupton, M. K., Hall, L.S., Montgomery, G W, Clarke, T.-K., Medland, S.E., Pattie, A., Martin, N.G., Liewald, D.C., Padmanabhan, S., Deary, I J, C Hayward, Smith, B.H., Hall, L S, Smith, B. H.; id_orcid, Fernandez-Pujals, A. M., Wright, M J, G W Montgomery, Hansell, N K, D C Liewald, Hall, L. S., N K Hansell, Wright, M. J., N G Martin, Hayward, C., S Cox, Liewald, D. C., Cox, S., Starr, J, Montgomery, G. W., I J Deary, Thomson, P. A., B H Smith, Deary, I. J., Fernandez-Pujals, A M, Lupton, M K, Hayward, C; id_orcid, M K Lupton, Davies, Gail, P A Thomson, Clarke, T-K, A M McIntosh, Hansell, N. K., Hansell, N.K., MacIntyre, D J; id_orcid, MacIntyre, D. J., L J Hocking, Smith, B. H., Cox, S, Fernandez-Pujals, A.M., Thomson, P.A., McIntosh, A M; id_orcid, M J Wright, Martin, N. G., Porteous, D.J., G Davies, Montgomery, G.W., Smith, B H, A M Fernandez-Pujals, McIntosh, A. M., A Pattie, D J MacIntyre, McIntosh, A.M., Clarke, T. K., S Padmanabhan, Medland, S. E., Pattie, A, Liewald, D C, L S Hall, Lupton, M.K., T-K Clarke, Padmanabhan, S, Martin, N G, MacIntyre, D.J., Deary, I.J.   +86 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic covariation among facets of openness to experience and general cognitive ability [PDF]

, 2008
Genetic and environmental sources of covariation among cognitive measures of verbal IQ, performance IQ (PIQ), academic achievement, 2-choice reaction time (CRT), inspection time (IT) and the 6 Openness facets of the NEO Personality Inventory-Revised (NEO
Wright, Margaret J., Luciano, Michelle, Wainwright, Mark A, Geffen, Gina M, Wright, Margaret J, Geffen, Gina M., Martin, Nicholas G., Wainwright, Mark A., Martin, Nicholas G   +8 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Developmental associations between traits of autism spectrum disorder and attention-deficit/hyperactivity disorder: a genetically-informative, longitudinal twin study [PDF]

, 2013
Background - Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and associated subclinical traits, regularly co-occur with one another. However, the aetiology of their co-occurrence remains poorly understood.
Ronald, Angelica, Charman, Tony; id_orcid, Plomin, R., Ronald, A, Charman, T., Happé, F, Asherson, P; id_orcid, Robinson, E.B., Asherson, P., Taylor, M J, Taylor, M.J., Plomin, R, Robinson, E B, Happé, F.   +13 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source