Results 201 to 210 of about 49,637 (294)

From Risks to Roots: The Multifactorial Etiopathogenesis of Childhood Obesity. [PDF]

Int J Mol Sci
Lupu VV, Nedelcu AH, Jechel E, Frasinariu OE, Forna L, Morariu ID, Anton E, Ghica DC, Puha B, Mihai CM, Fotea S, Chisnoiu T, Grigore E, Lupu A.   +13 more
europepmc   +1 more source

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source

Common and rare variant contributions to discontinuation of stimulant treatment in ADHD. [PDF]

Transl Psychiatry
Thirstrup JP, Duan J, Ribases Haro M, Soler Artigas M, Albiñana C, Dalsgaard S, Faraone SV, Werge T, Bybjerg-Grauholm J, Børglum AD, Agerbo E, Yao H, Chang Z, Brikell I, Demontis D.   +14 more
europepmc   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Genetic and environmental contributions to the link between synaesthesia and neurodevelopmental and psychiatric features: a twin study. [PDF]

Transl Psychiatry
Neufeld J, van Leeuwen TM, Kuja-Halkola R, Lundström S, Larsson H, Lichtenstein P, Bölte S, Mataix-Cols D, Taylor MJ.   +8 more
europepmc   +1 more source

Paternal alcoholism and offspring conduct disorder: Evidence for the \u27common genes\u27 hypothesis [PDF]

, 2005
Haber, Jon R, Heath, Andrew C, Jacob, Theodore   +2 more
core   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Amniotic Fluid Embolism in Donor Egg Twin Pregnancy: A Clinical Challenge in Critical Care. [PDF]

Cureus
Owies A, Attia A, John HT, Gajjar R, Abbas M.   +4 more
europepmc   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI-Exercise training reverses increased brain activity. [PDF]

Diabetes Obes Metab
Hentilä J, Tuisku J, Ojala R, Sun L, Lietzén MS, Virtanen H, Lautamäki R, Koskensalo K, Nummenmaa L, Löyttyniemi E, Helin S, Pietiläinen KH, Kaprio J, Lahti L, Malm T, Rinne JO, Hannukainen JC.   +16 more
europepmc   +1 more source