Results 51 to 60 of about 1,155,432 (278)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Consequences of fiscal deficit and public debt in financing the public sector [PDF]

Ekonomika Poljoprivrede (1979), 2014
The aim of this paper is to highlight the important issues of the budget deficit and public debt and their impact on economic growth. This paper considers the twin deficit hypothesis, which argues that there is a strong correlation between the current ...
Tešić Aleksandra, Ilić Dragan, Đelić Tanja Anastazija   +2 more
doaj   +1 more source

Case Report: A Case Study on the Neurodevelopmental Profile of a Child With Pallister–Killian Syndrome and His Unaffected Twin

Frontiers in Pediatrics, 2022
Pallister–Killian syndrome is an uncommon genetic disorder that has broad developmental and multisystemic effects. While medical complications are widely reported throughout the literature, research on the neurodevelopmental profile has been limited ...
Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Mary P. Hamzik, Kenneth Rosenbaum, Kosar Khaksari, Francie Mitchell, Ritika Kommareddi, Michaela R. Brooks, Elizabeth Tipton, Teresa Sadeghin, Andrea L. Gropman, Andrea L. Gropman   +12 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Globalization and social inequalities in Europe: assessment and outlook [PDF]

Eastern Journal of European Studies, 2012
The purpose of this article is to consider the social cohesion of the European Union which is today subjected to significant constraints by globalization and by the growing economic divergence between member States, especially in the Euro zone.
Hannah Brady, Bernard Yvars, Carmela MALTONE   +2 more
doaj  

Twin Deficit Phenomena in the Two Government Eras in Indonesia

Jurnal Analisis Bisnis Ekonomi, 2020
The aim of this study is to analyze the development of the budget deficit and current account deficit in Indonesia in the era of President SBY and President Jokowi and to compare between the two eras.
Muhammad Ghafur Wibowo
doaj   +1 more source

The Effect of Budget Deficit on Current Account Deficit in Ethiopia: Investigating the Twin Deficits Hypothesis

, 2018
This study investigated the relationship between government budget deficit and current account deficit in Ethiopia using annual data spanning the period 1976-2015. The analysis is based on a vector error correction model.
Teamrat Kahssay Gebremariam
semanticscholar   +1 more source

Twin deficits: squaring theory, evidence and common sense [PDF]

Economic Policy, 2006
In this paper we reconsider the twin deficit hypothesis (that fiscal shocks generating budget deficits also worsen external trade) both from a theoretical point of view and by analyzing data for Australia, Canada, the UK and the US. First, we assess the joint dynamics of budget and trade deficits along the business cycle, uncovering a strikingly ...
CORSETTI, Giancarlo, MÜLLER, Gernot J.
openaire   +3 more sources