Results 141 to 150 of about 1,984,424 (229)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

How adolescent cannabis use reshapes the developing brain - a systematic review. [PDF]

Front Psychiatry
Ricci V, Sarni A, De Berardis D, Martinotti G, Maina G.   +4 more
europepmc   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

The Potential of Digital Twins for Pediatric Rare Diseases. [PDF]

CPT Pharmacometrics Syst Pharmacol
Malik-Sheriff RS, Limdi A, Petsalaki E, Hermjakob H, McDonagh EM.   +4 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Washed microbiota transplantation improves clinical symptoms, gut microbiota, and metabolic profiles in autism spectrum disorder in a twin cohort. [PDF]

Front Microbiol
Feng S, Si X, Lu C, Gao Z, Wang J, Yang Q, Lu S, Su T, Yang J, He X, Wu L.   +10 more
europepmc   +1 more source

In Situ Alkali Metal Exfoliation‐Coupled Dilute CO2 Electrolysis to Synthesize Interlayer‐Expanded Graphite for High‐Rate Lithium Storage

Advanced Science, EarlyView.
Converting CO2 into advanced carbon materials capable of meeting the rapid lithium storage demands of lithium‐ion batteries creates a mutually beneficial scenario for both energy and environmental sectors. Here, we propose a stepwise CO2 electrolysis approach to transform dilute CO2 into interlayer‐expanded graphite using molten salt electrolyzers ...
Hao Zha, Xiaodan Zhang, Xinyu Li, Jiajun Li, Yuxin Wu, Xiaoyang Wang, Huayi Yin, Dihua Wang, Bowen Deng   +8 more
wiley   +1 more source

Autism spectrum disorder: has it lost its meaning and is it leading to misdiagnosis? [PDF]

Psychol Med
Frith U.
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Twins and their singleton siblings differ in language, cognition, and social-emotional development. [PDF]

Child Dev
Wood E, Brown A, von Stumm S.
europepmc   +1 more source