A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Super insulation material in district heating pipes [Elektronisk resurs] [PDF]
In Swedish district heating systems, 10% of the produced energy is lost at the distribution network. It is of interest to lower the energy losses both for economic and environmental reasons.
Adl-Zarrabi, Bijan,
core
Digital twin for a real-time leakage detection and localization in pressurized piping systems
ABSTRACT Leakages in water supply networks can be minimized through pressure reduction or by repairing the resulting damage. The effective implementation of the latter approach necessitates the localization of leaks, for which various methods exist.
Vanja Travaš +3 more
openaire +2 more sources
The cathode of proton exchange membrane water electrolyzers remains a poorly understood region despite its importance for hydrogen purity and operational safety. Operando synchrotron X‐ray radiography directly visualizes liquid water behavior and uncovers a transition from continuous to pulsating transport, providing new insight into multiphase ...
Wataru Yoshimune +2 more
wiley +1 more source
Predicting the Long-Term Insulation Performance of District Heating Pipes [PDF]
The aim of the studies that comprise this thesis was to predict the heat loss over time from a range of district heating pipes insulated with closed-cells foam.
Persson, Camilla
core
Thermally-Powered Autonomous Water Leakage Detection System for District Heating Pipes [PDF]
This article proposes a simple, low-cost, low-power standalone system for detecting leaks in district heating networks, employing time-domain reflectometry (TDR) powered by a twin-pipe temperature gradient.
Maurya, Poonam +14 more
core +1 more source
China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications
China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu +3 more
wiley +1 more source
Recent Advances and Development Trends of Global Top Drive Drilling Systems
In complex drilling scenarios such as deep wells, ultra-deep wells, extended-reach wells, and deep-water drilling, top drive systems (TDSs) can effectively shorten tripping time and reduce risks of stuck pipes, and have thus become indispensable key ...
Wang Bo +6 more
doaj +2 more sources
Emerging Memory and Device Technologies for Hardware‐Accelerated Model Training and Inference
This review investigates the suitability of various emerging memory technologies as compute‐in‐memory hardware for artificial intelligence (AI) applications. Distinct requirements for training‐ and inference‐centric computing are discussed, spanning device physics, materials, and system integration.
Yoonho Cho +6 more
wiley +1 more source
From Materials to Systems: Challenges and Solutions for Fast‐Charge/Discharge Na‐Ion Batteries
This review systematically analyzes the key characteristics limiting the fast‐charge/discharge capability of Na‐ion batteries (SIBs) from a multi‐scale perspective encompassing electrode materials, the electrode‐electrolyte interface, and the system. Furthermore, it presents practical solution strategies for the fundamental issues arising at each scale,
Bonyoung Ku +5 more
wiley +1 more source

