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International Journal of Pharmaceutics, 2015 Twin screw granulation (TSG) has been reported by different research groups as an attractive technology for continuous wet granulation. However, in contrast to fluidized bed granulation, granules produced via this technique typically have a wide and multimodal particle size distribution (PSD), resulting in suboptimal flow properties.
T de Beer, J P Remon
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Twin screw wet granulation: Granule properties
Chemical Engineering Journal, 2010Abstract Granulation is an important particle size enlargement process, used in many applications. Granulation has, for many years, been a batch process because of a greater knowledge base. However, the technique of using a twin screw granulator has been found to be very effective at granulating and is an attractive proposition for manufacturing ...
Ranjit M Dhenge +2 more
exaly +2 more sources
Twin screw granulation: Steps in granule growth
International Journal of Pharmaceutics, 2012The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied.
Ranjit M Dhenge +2 more
exaly +3 more sources
International journal of pharmaceutics, 2023
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size ...
H. Abdulhussain, M. R. Thompson
semanticscholar +1 more source
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size ...
H. Abdulhussain, M. R. Thompson
semanticscholar +1 more source
DEM analysis of residence time distribution during twin screw granulation
, 2021Twin screw granulation (TSG) is increasingly used to produce granules in various industries, such as food, pharmaceutical, and fine chemicals. However, there is a large parametric space in terms of screw designs, formulation properties and operating ...
Chao Zheng +3 more
semanticscholar +1 more source
Twin screw granulation as a simple and efficient tool for continuous wet granulation
International Journal of Pharmaceutics, 2004The modification of a twin screw extruder for continuous wet granulation was investigated. Modification of the extruder setup as well as the screw design allowed the continuous wet granulation of alpha-lactose monohydrate without the need of a wet sieving step.
A Vermeire, C Vervaet, J P Remon
exaly +3 more sources
Granulation of increasingly hydrophobic formulations using a twin screw granulator
International Journal of Pharmaceutics, 2014The application of twin screw granulation in the pharmaceutical industry has generated increasing interest due to its suitability for continuous processing. However, an understanding of the impact of formulation properties such as hydrophobicity on intermediate and finished product quality has not yet been established.
Gavin Reynolds, Agba D Salman
exaly +3 more sources
International journal of pharmaceutics, 2021
In this study, an image processing technique is implemented to measure complete two-dimensional particle size and liquid content distribution (2D-distribution) of the granules produced in twin screw granulation (TSG).
hys 05 +3 more
semanticscholar +1 more source
In this study, an image processing technique is implemented to measure complete two-dimensional particle size and liquid content distribution (2D-distribution) of the granules produced in twin screw granulation (TSG).
hys 05 +3 more
semanticscholar +1 more source
A review of twin screw wet granulation mechanisms in relation to granule attributes
Drug Development and Industrial Pharmacy, 2021Due to the trend of continuous pharmaceutical manufacturing, twin screw wet granulation (TSWG), a continuous process, has gained increased research interest as a potential substitution of traditional batch granulation processes. Despite the complex nature of TSWG, its mechanisms have been gradually unveiled with the aid of innovative research ...
Yi, Zhang +3 more
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Twin screw wet granulation: Binder delivery
International Journal of Pharmaceutics, 2015The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh +4 more
openaire +2 more sources