Results 191 to 200 of about 19,781 (230)
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International journal of pharmaceutics, 2020
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development.
A. Megarry +4 more
semanticscholar +1 more source
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development.
A. Megarry +4 more
semanticscholar +1 more source
Twin screw granulation – review of current progress
Drug Development and Industrial Pharmacy, 2014Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but ...
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Twin screw wet granulation: Effects of properties of granulation liquid
Powder Technology, 2012Abstract The effect of the properties of the granulation liquid, i.e. viscosity (amount of binder) and surface tension on residence time, torque and granule properties such as size, shape, structure, strength and flowability was studied in a co-rotating twin screw granulator.
Ranjit M Dhenge +2 more
exaly +2 more sources
International journal of pharmaceutics, 2020
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG ...
Kristina E. Steffens +4 more
semanticscholar +1 more source
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG ...
Kristina E. Steffens +4 more
semanticscholar +1 more source
Twin screw granulation: a simpler re-derivation of quantifying fill level.
International journal of pharmaceutics, 2020The fill level is defined as the volume occupied by the powder and granules inside the twin-screw granulator in proportion to the maximum barrel channel void 'free' volume.
Aquino L. Mundozah +4 more
semanticscholar +1 more source
Continuous twin screw extrusion for the wet granulation of lactose
International Journal of Pharmaceutics, 2002The suitability of continuous twin screw extrusion for the wet granulation of alpha-lactose monohydrate was studied and compared with conventional high shear granulation. The influence of process parameters (screw speed and total input rate) and formulation variables (water and polyvinylpyrrolidone (PVP) concentration) on the properties of granules ...
E I, Keleb +3 more
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International journal of pharmaceutics, 2020
This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process.
Judith Menth, M. Maus, K. Wagner
semanticscholar +1 more source
This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process.
Judith Menth, M. Maus, K. Wagner
semanticscholar +1 more source
Influence of filler selection on twin screw foam granulation
Drug Development and Industrial Pharmacy, 2013The influence of filler selection in wet granulation was studied for the novel case where the binder is delivered as an unstable, semi-rigid aqueous foam to an extrusion process. The work primarily examined the impact of differing concentrations of microcrystalline cellulose (Avicel PH® 101) in a formulation with spray-dried α-lactose monohydrate ...
K E, Rocca +3 more
openaire +2 more sources
Advanced Powder Technology, 2019
Process analytical technologies (PAT) are identified as an essential element in the Quality by Design framework, providing the cornerstone to implement continuous pharmaceutical manufacturing.
Wei Meng +6 more
semanticscholar +1 more source
Process analytical technologies (PAT) are identified as an essential element in the Quality by Design framework, providing the cornerstone to implement continuous pharmaceutical manufacturing.
Wei Meng +6 more
semanticscholar +1 more source
International journal of pharmaceutics, 2019
Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables ...
Wei Meng +4 more
semanticscholar +1 more source
Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables ...
Wei Meng +4 more
semanticscholar +1 more source