Results 201 to 210 of about 19,781 (230)

A study of foam granulation and wet granulation in a twin screw extruder

The Canadian Journal of Chemical Engineering, 2012
AbstractThis research investigated a new technique known as foam granulation for the continuous manufacturing of pharmaceuticals by a twin screw extruder. Six grades of hypromellose were compared as binders in the trials, using two addition methods: foam injection by auxiliary side stuffer feeder and liquid injection directly into the extruder.
S. Weatherley, M.R. Thompson, P.J. Sheskey   +2 more
openaire   +1 more source

Granulation rate processes in the kneading elements of a twin screw granulator

AIChE Journal, 2013
To characterize the granulation rate processes in the kneading section of the twin screw granulator, separate experiments were conducted using exclusively conveying elements as the baseline in addition to different configurations of kneading elements. The configuration parameters examined were the length of the kneading section, the advance angle, and ...
A. S. El Hagrasy, J. D. Litster
openaire   +1 more source

Continuous twin screw granulation: Impact of the starting material properties and various process parameters

Powder Technology, 2019
The purpose of this study is to confirm the correlation between the formulation factors and the process parameters using multivariate analysis (MVA) during twin screw granulation.
Kyu-Min Hwang, Cheol‐Hee Cho, Seung-Dong Yoo, Kwan-Ik Cha, E. Park   +4 more
semanticscholar   +1 more source

Development of prediction model with machine learning in continuous twin screw granulation

Journal of Pharmaceutical Investigation, 2023
Seung-Dong Yoo, J. Y. Kim, Sung-Kyun Han, Byung-Hoon Lee, D. Choi, eun-seok Park   +5 more
semanticscholar   +1 more source

Twin screw wet granulation: The study of a continuous twin screw granulator using Positron Emission Particle Tracking (PEPT) technique

European Journal of Pharmaceutics and Biopharmaceutics, 2012
In this paper, Positron Emission Particle Tracking (PEPT) techniques are utilised to track the trajectory of single particles through the mixing and conveying zones of a Twin Screw Granulator (TSG). A TSG consisting of conveying zones and mixing zones is used in this study. The mixing zones are arranged with kneading discs at an angle of 30°, 60° or 90°
Kai T, Lee, Andy, Ingram, Neil A, Rowson
openaire   +2 more sources

Heat assisted twin screw dry granulation

AIChE Journal, 2017
A new “assisted” dry granulation method has been devised for the twin‐screw granulator. The method may be beneficial to drug preparation as it limits heat exposure to only one barrel zone, much shorter than melt granulation. Its mechanism was investigated using four placebo formulations, each containing a polymer binder with a glass transition ...
Y. Liu, M. R. Thompson, K. P. O'Donnell, S. Ali   +3 more
openaire   +1 more source

Hydrophobic/hydrophilic powders: Practical implications of screw element type on the reduction of fines in twin screw granulation

Powder Technology, 2019
This study focuses on the role that various screw elements play in the reduction of fines in twin screw wet granulation (TSG) when using increasing amounts of hydrophobic component in the formulation.
Aquino L. Mundozah, James J. Cartwright, Claire C. Tridon, M. Hounslow, A. Salman   +4 more
semanticscholar   +1 more source

Assessing particle segregation using near-infrared chemical imaging in twin screw granulation.

International journal of pharmaceutics, 2019
In the present study the application of near-infrared chemical imaging (NIR-CI) for assessing particle segregation in granules from continuous twin screw granulation (TSG) granules, were the complex attributes of the machinery configuration in relation ...
Aquino L. Mundozah, Jiankai Yang, Claire C. Tridon, James J. Cartwright, Chalak S. Omar, A. Salman   +5 more
semanticscholar   +1 more source

Risk Assessment for a Twin-Screw Granulation Process Using a Supervised Physics-Constrained Auto-encoder and Support Vector Machine Framework

Pharmaceutical Research, 2022
Chaitanya Sampat, R. Ramachandran
semanticscholar   +1 more source

Model Driven Design for Twin Screw Granulation using Mechanistic-based Population Balance Model.

International journal of pharmaceutics, 2021
Li Ge Wang, J. Morrissey, D. Barrasso, D. Slade, S. Clifford, G. Reynolds, J. Ooi, J. Litster   +7 more
semanticscholar   +1 more source