Results 101 to 110 of about 785,061 (339)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Heritability of decisions and outcomes of public goods games

Frontiers in Psychology, 2015
Prosociality is one of the most distinctive features of human beings but there are individual differences in cooperative behavior. Employing the twin method, we examined the heritability of cooperativeness and its outcomes on public goods games using a ...
Kai eHiraishi, Chizuru eShikishima, Shinji eYamagata, Juko eAndo   +3 more
doaj   +1 more source

Multicomponent Bright Solitons in F = 2 Spinor Bose-Einstein Condensates

, 2007
We study soliton solutions for the Gross--Pitaevskii equation of the spinor Bose--Einstein condensates with hyperfine spin F=2 in one-dimension. Analyses are made in two ways: by assuming single-mode amplitudes and by generalizing Hirota's direct method ...
\cabrowska-Wüster B. J. D, Burger S., Chang M.-S., Ciobanu C. V., Crosignani B., Denschlag J., Diener R. B., Görlitz A., Hirota R., Ho T.-L., Ieda J., Ieda J., Ieda J., Khaykovich L., Kuwamoto T., Li L., Manakov S. V., Miesner H.-J., Ohmi T., Pogosov W. V., Saito H., Schmaljohann H., Stamper-Kurn C. M., Stenger J., Strecker K. E., Tsuchida T., Tsuchida T., Uchiyama M., Ueda M., Wadati M., Widera A., Zakharov V. E., Zakharov V. E., Zakharov V. E., Zhang W.   +34 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Quantitative variability of 342 plasma proteins in a human twin population

Molecular Systems Biology, 2015
The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different ...
Yansheng Liu, Alfonso Buil, Ben C Collins, Ludovic CJ Gillet, Lorenz C Blum, Lin‐Yang Cheng, Olga Vitek, Jeppe Mouritsen, Genevieve Lachance, Tim D Spector, Emmanouil T Dermitzakis, Ruedi Aebersold   +11 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Do different measures tap the same genetic influences? A multi‐method study of activity level in young twins [PDF]

, 2009
Kimberly J. Saudino
openalex   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins

Epigenomes
Background/Objectives: The dynamic interaction between genomic DNA, epigenetic modifications, and phenotypic traits was examined in identical twins. Environmental perturbations can induce epigenetic changes in DNA methylation, influencing gene expression
Yoichi Takenaka, Osaka Twin Research Group, Mikio Watanabe   +2 more
doaj   +1 more source