Results 321 to 330 of about 41,814,406 (368)

Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study. [PDF]

Behav Genet
Bruins S, van Bergen E, Masselink MW, Barzeva SA, Hartman CA, Otten R, Rommelse NNJ, Dolan CV, Boomsma DI.   +8 more
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume. [PDF]

Dev Cogn Neurosci
van Drunen L, Dobbelaar S, Crone EA, Wierenga LM.   +3 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins. [PDF]

J Atheroscler Thromb
Nishihara S, Koseki M, Tanaka K, Omatsu T, Sawabe H, Inui H, Saga A, Okada T, Higo T, Ohama T, Nishida M, Sakata Y, Watanabe M, Osaka Twin Research Group.   +13 more
europepmc   +1 more source

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A Twin Study of Alexithymia

Psychotherapy and Psychosomatics, 2001
<i>Background:</i> Factors contributing to the development of alexithymia and the nature of alexithymia’s relation with trait negative and positive affectivity are unclear. In this study, a twin approach was used to examine the degree of genetic and environmental contributions to the different facets of alexithymia, and the nature of their ...
Howard Berenbaum, Eve M. Valera
openaire   +3 more sources

TWIN STUDIES ON SENESCENCE

American Journal of Psychiatry, 1949
1. By means of the twin family method and up to the end of 1947, a representative sample of 1,602 twin index cases over 6o years of age was collected from both the general and institutionalized populations of the state of New York, in order to study the biological, social, and psychiatric problems of senescence under experiment-like, but mankind ...
Gerhard Sander, Franz J. Kallmann
openaire   +3 more sources

Twin studies of pain

Clinical Genetics, 2012
Twin studies provide a method for estimating the heritability of phenotypes and for examining genetic and environmental relationships between phenotypes. We conducted a systematic review of twin studies of pain, including both clinical and experimental pain phenotypes. Fifty‐six papers were included, whereof 52 addressed clinical phenotypes.
Gun Peggy Knudsen, Christopher Sivert Nielsen, Ólöf Anna Steingrímsdóttir   +2 more
openaire   +3 more sources

Twin Study on Myopia

Acta geneticae medicae et gemellologiae: twin research, 1987
AbstractIn order to reassess the relative importance of genetic and environmental factors in the development of myopia in Chinese schoolchildren, 90 pairs of MZ and 36 pairs of like-sex DZ twins were enrolled for detailed ophthalmological examination about their ocular refractions. Corneal curvatures and axial lengths were also measured.
L.L.-K. Lin, C.-J. Chen
openaire   +3 more sources