Results 61 to 70 of about 41,814,406 (368)

A study of twins and stroke. [PDF]

open access: yesStroke, 1992
Although there are strong genetic contributions to coronary artery disease, only a few studies have considered heritable influences on stroke. We investigated the role of genetic factors in stroke using the Twin Registry maintained by the National Academy of Sciences-National Research Council. The registry includes 15,948 male twin pairs born
C. Robinette   +3 more
openaire   +3 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

open access: yesFEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

ASAS Census of Twins [PDF]

open access: yes, 2020
Twin binaries were identified among the eclipsing binaries with $\delta$>--30$^\circ$ listed in the ASAS catalog. In addition to the known twin binaries in the literature, 68 new systems have been identified, photometric and spectroscopic observations were done.
arxiv   +1 more source

Heritability of clubfoot: A twin study [PDF]

open access: yesJournal of Children's Orthopaedics, 2014
Introduction The aetiology of congenital clubfoot is unclear. Although studies on populations, families, and twins suggest a genetic component to the aetiology, other studies have identified environmental factors. The purpose of this study was to calculate heritability in order to determine to what extent genetic and/or environmental factors contribute
Engell, Vilhelm   +7 more
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Imbalance Parameterized by Twin Cover Revisited [PDF]

open access: yesarXiv, 2020
We study the problem of Imbalance parameterized by the twin cover of a graph. We show that Imbalance is XP parameterized by twin cover, and FPT when parameterized by the twin cover and the size of the largest clique outside the twin cover. In contrast, we introduce a notion of succinct representations of graphs in terms of their twin cover and ...
arxiv  

Exotic Quarks in Twin Higgs Models [PDF]

open access: yes, 2015
The Twin Higgs model provides a natural theory for the electroweak symmetry breaking without the need of new particles carrying the standard model gauge charges below a few TeV. In the low energy theory, the only probe comes from the mixing of the Higgs fields in the standard model and twin sectors. However, an ultraviolet completion is required below ~
arxiv   +1 more source

Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study [PDF]

open access: yesTwin Research and Human Genetics, 2019
The Children of the Twins Early Development Study (CoTEDS) is a new prospective children-of-twins study in the UK, designed to investigate intergenerational associations across child developmental stages. CoTEDS will enable research on genetic and environmental factors that underpin parent-child associations, with a focus on mental-health and cognitive
Mcmillan , Andrew   +7 more
openaire   +5 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

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