Results 71 to 80 of about 41,814,406 (368)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Heritability of decisions and outcomes of public goods games

Frontiers in Psychology, 2015
Prosociality is one of the most distinctive features of human beings but there are individual differences in cooperative behavior. Employing the twin method, we examined the heritability of cooperativeness and its outcomes on public goods games using a ...
Kai eHiraishi, Chizuru eShikishima, Shinji eYamagata, Juko eAndo   +3 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Causes of blood methylomic variation for middle-aged women measured by the HumanMethylation450 array

Epigenetics, 2017
To address the limitations in current classic twin/family research on the genetic and/or environmental causes of human methylomic variation, we measured blood DNA methylation for 479 women (mean age 56 years) including 66 monozygotic (MZ), 66 dizygotic ...
Shuai Li, Ee Ming Wong, Tuong L. Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S. Dite, Graham G. Giles, Richard Saffery, Melissa C. Southey, John L. Hopper   +9 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Prevalence and heritability of parental‐reported speech and/or language difficulties in a Swedish population‐based twin sample

JCPP Advances
Background Research on genetic and environmental influences on speech and/or language difficulties (SaLD) is sparse, with inconsistent heritability estimates. We aimed to estimate the prevalence of parental reported SaLD and the relative contributions of
Rebecka Keijser, Jakob Åsberg Johnels, Marika Habbe, Paul Lichtenstein, Henrik Larsson, Sebastian Lundström, Mark J. Taylor, Kristiina Tammimies   +7 more
doaj   +1 more source

Thermally induced changes of structure in Ni$_{50}$Mn$_{25+x}$Ga$_{25-x}$ magnetic shape memory single crystals with very low twinning stress [PDF]

Smart Mater. Struct. 25 025001 (2016), 2014
In search for the origins of the extraordinary low twinning stress of Ni-Mn-Ga magnetic shape memory alloys we studied the thermally induced changes of structure in Ni$_{50}$Mn$_{25+x}$Ga$_{25-x}$ ($x$=2.7--3.9) single crystal samples and compared them with twinning stress dependences.
arxiv   +1 more source

Digital twin-based sustainable intelligent manufacturing: a review

Advances in Manufacturing, 2020
As the next-generation manufacturing system, intelligent manufacturing enables better quality, higher productivity, lower cost, and increased manufacturing flexibility.
Bin He, Kai-Jian Bai
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

Frontiers in Immunology, 2017
Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Sanna Kaye, Sanna Kaye, A. Inkeri Lokki, A. Inkeri Lokki, A. Inkeri Lokki, Anna Hanttu, Eija Nissilä, Eija Nissilä, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Lilli Saarinen, Olli Tynninen, Maheswary Muniandy, Maheswary Muniandy, Aila Rissanen, Aila Rissanen, Jaakko Kaprio, Jaakko Kaprio, Seppo Meri, Seppo Meri, Kirsi H. Pietiläinen, Kirsi H. Pietiläinen   +23 more
doaj   +1 more source