This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Mortalidad perinatal en gestaciones múltiples: Hospital Miguel Servet, Zaragoza, España: 2000-2009
Objetivos: Evaluar la mortalidad perinatal (MP) de las gestaciones múltiples del Hospital Miguel Servet de Zaragoza (2000-2009). Método: Análisis, sobre un total de 44.401 recién nacidos (RN) >500 gramos, de 92 nacidos muertos ó fallecidos antes de los ...
Esther Cruz G +5 more
doaj
Conclusion: the future of digital twins and their transformative impact [PDF]
openalex +1 more source
Multi-silicone bilateral soft physical twin as an alternative to traditional user interfaces for remote palpation: a comparative study [PDF]
Leone Costi, Fumiya Iida
openalex +1 more source
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
The Necessity of Development and Implementation of Twins Registry in Iran
Introduction: In the last three decades, national twins registries have been developed throughout the world with the aim of studying unique genetic characteristics and the possibility of determining the genotypic effects.
Hamidreza Abtahi +2 more
doaj
Origin of profuse {11
Cong He +5 more
openalex +2 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue [PDF]
Lianlian Wang +12 more
openalex +1 more source

