Results 171 to 180 of about 561,765 (333)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Anesthetic Management in the Elective Separation of Omphalopagus Conjoined Twins With Shared Hepatic Parenchyma: A Case Report. [PDF]

Cureus
Godinho I, Paulos J, Pinto Carneiro A.
europepmc   +1 more source

To sink, swim, twin, or nucleate: A critical appraisal of crystal aggregation processes [PDF]

, 2019
Penny Wieser, Zoja Vukmanovic, Rüdiger Kilian, Emilie Ringe, Marian B. Holness, John Maclennan, Marie Edmonds   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Risk factors for hemodynamically significant patent ductus arteriosus and ibuprofen treatment failure in premature twins: a retrospective case-control study. [PDF]

Front Cardiovasc Med
Gao B, Zhao Y, Li H, Du Y, Wu Y, Chen G, Wang P.   +6 more
europepmc   +1 more source

Atypical twin–twin transfusion syndrome

Ultrasound in Obstetrics & Gynecology, 2022
A. Khalil, S. Prasad, R. Cruz‐Martínez   +2 more
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Author Correction: Densely vascularized thick 3D tissue shows enhanced protein secretion constructed with intermittent positive pressure

Communications Biology
Misako Katsuura, Jun Homma, Yuhei Higashi, Hidekazu Sekine, Tatsuya Shimizu   +4 more
doaj   +1 more source

Epilepsy concordance in monozygotic twins: the role of common genetic variants. [PDF]

Brain
Dang YL, Oliver KL, Esnault K, Bahlo M, Perucca P, Berkovic SF.   +5 more
europepmc   +1 more source

EXPERIMENTAL AND NUMERICAL INVESTIGATION ON MANEUVERING PERFORMANCE OF SMALL WATERPLANE AREA TWIN HULL

, 2021
Kun Dai, Yunbo Li
openalex   +1 more source