Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Features of nucleation and evolution of defect structure in vanadium under constrained deformation [PDF]
, 2017 Atomic mechanisms of structural transformations leading to fragmentation in vanadium under deformation in constrained conditions without changing its volume are investigated on the basis of the molecular dynamics method.
Korchuganov, Aleksandr V. +2 more
core
A syntactic-semantic analysis of English (non)-dativizable constructions in the production of a set of 2L1 English/Spanish simultaneous bilingual twins [PDF]
, 2016 This paper analyzes the syntactico-semantic factors which trigger Dative shift in English dativizable verbs, i.e. those verbs that allow alternation between double object and prepositional complement constructions.
Fernandez Fuertes, Raquel +1 more
core +3 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Erratum: Neuroblastoma in monozygotic twins – a case of probable twin to twin metastasis [PDF]
British Journal of Cancer, 2001 Concordance for neuroblastoma in monozygotic twins has been reported only rarely, and the cause of the shared pathology has not been established. We describe a case of infant monozygotic twins developing tumours that were morphologically, clinically and molecularly indistinguishable, but with a delay of 6 months between times of presentation.
Tony Gordon +5 more
openaire +3 more sources
Identical twin Steiner triple systems [PDF]
, 2016 Two Steiner triple systems, each containing precisely one Pasch configuration which, when traded, switches one system to the other, are called twin Steiner triple systems. If the two systems are isomorphic the systems are called identical twins. Hitherto,
Grannell, M. J., Lovegrove, G. J.
core
Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in Crohn's Disease [PDF]
, 2010 Inflammatory bowel diseases (IBD), such as Crohn’s disease, are chronic, immunologically mediated disorders that have severe medical consequences.
Claire M. Fraser-Liggett
core +2 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Is the solar spectrum latitude dependent? An investigation with SST/TRIPPEL [PDF]
, 2011 Context: In studies of the solar spectrum relative to spectra of solar twin stars, it has been found that the chemical composition of the Sun seems to depart systematically from those of the twins.
Allende Prieto +21 more
core +2 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source