Results 241 to 250 of about 135,103 (314)

Synthesis of β‐Hydroxy‐α,α‐dimethyl Carboxylic Esters via Asymmetric Barbier Reaction

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
Despite the occurrence of the β‐hydroxy‐α,α‐dimethyl carboxylic ester motif in many natural products no attempt was made to synthesize this core structure via a racemic and enantioselective Barbier reaction. In this study, the optimized reaction conditions for the achiral Barbier reaction between allyl bromide and a 2,2‐dimethyl‐3‐oxopropanoate were ...
Jan Grammel   +4 more
wiley   +1 more source

New Glycoconjugates Containing Selenium and Polyphenols. Stereoselective Synthesis by Pummerer‐like Rearrangement

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
In the last 20 years the exploitation of antioxidant activity of selenobased compounds has improved, just due to the use of Ebselen, a selenocompound, as a Glutathione peroxidase (GPx) mimic. However, their clinical use seems to be compromised by the low solubility in water.
Claudia González   +6 more
wiley   +1 more source

Enantioselective Anion‐Binding‐Catalyzed Nucleophilic Addition to 4‐Quinolones

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
Chiral quinolones and their derivatives are predominant synthetic building blocks and pharmacological agents. Nevertheless, their synthesis mostly relies on transition‐metal‐catalyzed enantioselective 1,4‐additions of organometallic reagents such as Grignard, organozinc or organoboron species for alkylation, arylation and alkynylation reactions. Herein,
Martin Aleksiev   +2 more
wiley   +1 more source

Exploring public perceptions of dementia on Twitter (X): a cross-cultural analysis. [PDF]

open access: yesAlzheimers Dement
Srikajornlarp S   +4 more
europepmc   +1 more source

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