Results 41 to 50 of about 4,012,092 (280)

Causes of overweight and obesity in children and adolescents

open access: yesJournal of Education, Health and Sport, 2020
Obesity is caused by positive energy balance. Excessive body weight in children is classified by using charts for body mass index (BMI). The prevalence of overweight and obesity is a growing public health problem worldwide.
Agnieszka Danuta Maślak   +4 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

A Number of Quasi-Exactly Solvable N-body Problems [PDF]

open access: yes, 1998
We present several examples of quasi-exactly solvable $N$-body problems in one, two and higher dimensions. We study various aspects of these problems in some detail. In particular, we show that in some of these examples the corresponding polynomials form
Avinash Khare   +2 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Detailed Analysis of the Dynamics of Two Point Masses Under Gravitational Interaction

open access: yesAstronomy
The dynamics of two point masses interacting in a gravitational field has been the object of several scientific works. However, the complete explicit solution of the two-body problem is, to the best of our knowledge, not always available in the ...
Luigi Sirignano   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

An efficient Generalized Geometry Contact algorithm including modal reduction flexible bodies

open access: yesMechanical Engineering Journal, 2017
In the MFBD (Multi-Flexible-Body Dynamics) (RecurDyn, 2017), the contact analysis is very important. To develop the general purpose contact algorithm for rigid and flexible bodies, the Generalized Geometry Contact algorithm, which is called ‘Geo Contact ...
Ho-Young CHA   +3 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Some boundary value problems for a micropolar porous elastic body

open access: yesArchives of Mechanics, 2020
The paper reviews the static equilibrium of a micropolar porous elastic material. We assume that the body under consideration is an elastic Cosserat media with voids, however, it can also be considered as an elastic microstretch solid, since the basic ...
R. Janjgava, B. Gulua, S. Tsotniashvili
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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