Results 41 to 50 of about 20,875,315 (249)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
New insights into the interactions between two‐dimensional ice and two‐dimensional materials
Droplet, 2023 Water is one of the most essential substances for life on Earth and plays a vital role in both natural and technological processes. Recently, there has been growing interest in studying the behavior of water molecules in confined spaces, particularly in ...
Quoc Huy Thi, Jiong Zhao, Thuc Hue Ly
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Vapor phase growth of two-dimensional Cr2O3 nanosheets with non-equilibrium charge conduction
Nano ResearchTwo-dimensional (2D) materials, especially 2D transition metal oxides (TMOs), have garnered significant research attention due to their unique physical and chemical properties and vast potential applications in electronics, optoelectronics, magneto ...
Jianteng Liu +11 more
doaj +1 more source
Two dimensional Airy beam soliton
Scientific Reports, 2022 We demonstrate the formation of a two dimensional Airy beam soliton in a photorefractive crystal. By simply varying the nonlinearity strength we identify several scenarios showing the coexistence between an Airy beam and the emerging soliton. The soliton
Thomas Bouchet +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source