Results 221 to 230 of about 486,920 (279)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Complex motor imagery in elite female ice hockey players: a cortical arena of imagination revealed by magnetoencephalography. [PDF]

Front Hum Neurosci
Potts AA, Garcia Dominguez L, Gold D, McAndrews MP, Wennberg R.   +4 more
europepmc   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Pedunculopontine-thalamic cholinergic projections in rapid eye movement sleep behaviour disorder. [PDF]

NPJ Parkinsons Dis
Schumacher J, Teipel S, Storch A, Hermann W.   +3 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Repetitive transcranial magnetic stimulation promotes the recovery of upper limb motor dysfunction in ischemic stroke patients: a DTI-based glymphatic system imaging prospective study. [PDF]

PeerJ
Dong Y, Liu J, Wang T, Zhang Z, Hu X, Zhu C, Gao M, Yan P, Lei H, Zhou J.   +9 more
europepmc   +1 more source

DC‐magnetometry Analytical Tool Driven by Spin Ordering Phenomena for Sensing Chemical Interactions at the Surface of Nanomaterials

Advanced Science, EarlyView.
The adsorption of AsV on akaganeite nanorods was found to provide a magnetic signature. A change in the surface spin order gave rise to a second peak in the zero‐field cooled curve. AsIII adsorption does not provide any change in the magnetic behavior of the sorbent.
Marco Sanna Angotzi, Valentina Mameli, Alessandra Fantasia, Cesare Atzori, Giovanni Bertoni, Vincenzo Grillo, Giorgio Divitini, Dominika Zakutna, Jana Vejpravova, Martin Kalbac, Jan Plšek, Carla Cannas   +11 more
wiley   +1 more source

Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study. [PDF]

Imaging Neurosci (Camb)
Kransberg J, Sjøli Bråthen AC, Falch ES, Øverbye KEØ, Garrido PF, Fjell AM, Stangl M, Wolbers T, Sneve MH, Walhovd KB.   +9 more
europepmc   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Southern Hemisphere initiation of the mid-Pleistocene transition. [PDF]

Sci Adv
Basak C, Kapuge AKIU, Farmer JR, Symes E, Middleton JL, Gottschalk J, Arz HW, Lamy F, Winckler G, Cruz APS.   +9 more
europepmc   +1 more source