Results 181 to 190 of about 33,170,271 (311)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Aligning Minds in Spasticity Care-A Two-Phase Delphi-Dialogue Study of Patients and Professionals in Spain. [PDF]

Toxins (Basel)
Bascuñana-Ambrós H, Formigo-Couceiro J, Climent-Barberá JM, Guirao-Cano L, Catta-Preta M, Trejo-Omeñaca A, Monguet-Fierro JM.   +6 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Two-Phase Orthodontic Treatment in an Adolescent With a 15 mm Severe Overjet. [PDF]

Cureus
Xu S, Li X, Zhang Y, Li W.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Degradable polyphosphoester-based aqueous two-phase systems and water-in-water emulsions. [PDF]

Chem Sci
McCone JAJ, Elshof RT, Bayliss N, Wurm FR, Schmidt BVKJ.   +4 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Spontaneous Fusion of Aqueous Two-Phase Droplets: Effect of Coexisting Phospholipids on Stability. [PDF]

Chembiochem
Shono M, Inoue M, Yamamoto D, Yanagisawa M, Yoshikawa K, Shioi A.   +5 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Development of an AI chatbot to support shared decision-making in rheumatoid arthritis: a two-phase usability study. [PDF]

BMC Med Inform Decis Mak
Choi SR, Yoon S, Lee SB, Park HR, Ko HR, Jung YS, Nam E, Cho SK, Sung YK.   +8 more
europepmc   +1 more source