Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Disintegration Mechanism of Coal-Bearing Soil Based on Granularity Entropy and Water-Air Two-Phase Flow. [PDF]
Lyu G, Zheng M, Xiong L, Liu Z, Zhang H.
europepmc +1 more source
Implementing Contact Angle Hysteresis in Moving Mesh-Based Two-Phase Flow Numerical Simulations. [PDF]
Cai Z, Song Y.
europepmc +1 more source
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Research Progress and Current Status of Gas-Solid Two-Phase Flow Technology in the Direction of Laser Cladding. [PDF]
Peng J+6 more
europepmc +1 more source
Improved Permeability Model of the Binary Gas Interaction within a Two-Phase Flow and its Application in CO2-Enhanced Coalbed Methane Recovery. [PDF]
Wang G+6 more
europepmc +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Performance Comparison of Proton Exchange Membrane Water Electrolysis Cell Using Channel and PTL Flow Fields through Three-Dimensional Two-Phase Flow Simulation. [PDF]
Park S, Lee W, Na Y.
europepmc +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Modelling pressure dynamics of oil-gas two-phase flow in double-porosity media formation with permeability-stress sensitivity. [PDF]
Zhang C+7 more
europepmc +1 more source