Results 71 to 80 of about 1,297,363 (263)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Fluctuating Characteristics of Two-Phase Air-Water Slug Flow in Pressurized Pipelines [PDF]
آب و فاضلاب, 2009 Two-phase gas-liquid flows occur in a wide variety of situations, e.g., in chemical processing, power generation, water supply systems, and petroleum industry. The study of two-phase fluid flows is of great importance in hydraulic engineering.
Abdorreza Kabiri-Samani
doaj
Nihon Kikai Gakkai ronbunshu, 2014 This study aims to investigate the horizontally oriented internal two-phase flow induced force fluctuations. Gas-liquid two-phase flow experiments were conducted on 90 degree pipe bend, oriented horizontal-downwardly. Multiple tri-axial force transducers
Shuichiro MIWA +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A Mathematical Model for The Performance of Solar Heating Driven Bubble Pumps
Solar Energy and Sustainable Development, 2018 A mathematical model of the bubble pump is established by employing the governing equations; the continuity, momentum and energy equations. The model was used to evaluate the performance of the pump under different geometrical and operational conditions.
Khaled Elshawesh +2 more
doaj
The Two-Phase Hell-Shaw Flow: Construction of an Exact Solution
International Journal of Applied Mechanics and Engineering, 2013 We consider a two-phase Hele-Shaw cell whether or not the gap thickness is time-dependent. We construct an exact solution in terms of the Schwarz function of the interface for the two-phase Hele-Shaw flow.
K.R. Malaikah
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source