Results 291 to 300 of about 367,886 (378)

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Establish operating conditions for optimal output characteristics in reactivity controlled combustion engine. [PDF]

Sci Rep
Muniyappan S, Krishnaiah R.
europepmc   +1 more source

SIRT6 Lysine‐Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE‐Cadherin Pathway Regulating Vascular Endothelial Barrier

Advanced Science, EarlyView.
A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng, Zheyan Fang, Shuang Zhao, You‐en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li   +40 more
wiley   +1 more source

Engine performance and emission optimization with waste cooking oil biodiesel/diesel blend using ANN and RSM techniques coupled with ACKTR-DE and HHO algorithms. [PDF]

BMC Chem
Biberci MA, Çelik MB, Ozhuner E.
europepmc   +1 more source

Molecular Creep Induced Fatigue Rupture of Fibrin Clots

Advanced Science, EarlyView.
Fibrin networks in thrombi paradoxically exhibit low fatigue resistance despite high fracture energy, as cyclic loading triggers irreversible α‐to‐β transitions in fibrin molecules, causing molecular creep, crack propagation. Multiscale experiments, modeling reveal how nanoscale conformational damage accumulates, linking molecular disorder to ...
Dani Liu, Zichang Jia, Binchao Liu, Jizhe Hou, Rui Bao, Mingkun Wang   +5 more
wiley   +1 more source

Production and Characterization of Open Cell Cordierite from Boron and Waste Materials by Geopolymer Method for the Emission After Treatment System of Diesel Engines. [PDF]

Glob Chall
Ergun Y, Caliskan H, Karali HI.
europepmc   +1 more source

Upper Limb Motor Function Rehabilitation System Leveraging Pressure‐Sensitive Intent Recognition

Advanced Science, EarlyView.
A novel upper limb rehabilitation system for stroke patients combines liquid metal elastomer sensors with functional electrical stimulation (FES). By automatically adjusting stimulation intensity based on real‐time muscle force signals, the system enhances wrist movement capability (14° to 47° elevation) and aids neural recovery through heightened ...
Zhiwei Hu, Yongchao Yin, Xiaoli Yang, Hanyang Zhang, Ling Xing, Shiwu Zhang, Xinglong Gong, Ming Wu, Guolin Yun, Shuaishuai Sun   +9 more
wiley   +1 more source

Sustainable RCCI engine operation with an ANN based novel tri-fuel approach. [PDF]

Sci Rep
Elumalai PV, Shieh CS, Reddy MS, Sree SR, Krishnan S.   +4 more
europepmc   +1 more source

Advances in Medical Devices for Augmented Acupuncture Therapy

Advanced Science, EarlyView.
Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai, Chenyi Yu, Xinyi Luo, Ningyu Xu, Jicheng Yu, Xiao Ye, Yuqi Zhang, Zhen Gu   +7 more
wiley   +1 more source

RDE & dynamometer analysis of light-duty vehicle emissions across altitudes, temperatures, and driving styles. [PDF]

PLoS One
Wang J, Wang L, Li J, Li J, Xu F, Han F, He J, Chen Q, Chen X.   +8 more
europepmc   +1 more source