Results 61 to 70 of about 167,996 (242)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Short-Interval Averages of Sums of Fourier Coefficients of Cusp Forms
, 2016 Let $f$ be a weight $k$ holomorphic cusp form of level one, and let $S_f(n)$ denote the sum of the first $n$ Fourier coefficients of $f$. In analogy with Dirichlet's divisor problem, it is conjectured that $S_f(X) \ll X^{\frac{k-1}{2} + \frac{1}{4 ...
Hulse, Thomas A. +3 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Functional limit theorems for sums of independent geometric L\'{e}vy processes
, 2011 Let $\xi_i$, $i\in \mathbb {N}$, be independent copies of a L\'{e}vy process $\{\xi(t),t\geq0\}$. Motivated by the results obtained previously in the context of the random energy model, we prove functional limit theorems for the process \[Z_N(t)=\sum_{i ...
Kabluchko, Zakhar
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On the sixth power mean of the two-term exponential sums
Journal of Number Theory, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhang, Wenpeng, Han, Di
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The prime geodesic theorem for $\mathrm{PSL}_{2}(\mathbb{Z}[i])$ and spectral exponential sums
, 2020 We shall ponder the Prime Geodesic Theorem for the Picard manifold $\mathcal{M} = \mathrm{PSL}_{2}(\mathbb{Z}[i]) \backslash \mathfrak{h}^{3}$, which asks about the asymptotic behaviour of a counting function for the closed geodesics on $\mathcal{M ...
Kaneko, Ikuya
core
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
On the hybrid power mean of two kind different trigonometric sums
Open Mathematics, 2019 The main purpose of this paper is using the analytic method, the properties of trigonometric sums and Gauss sums to study the computational problem of one kind hybrid power mean involving two different trigonometric sums, and give an interesting ...
Zhuoyu Chen, Wenpeng Zhang
doaj +1 more source