Results 121 to 130 of about 24,764,004 (235)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Multiscale Characterization of Flow Instability for Gas-Liquid Two-Phase Flow. [PDF]

Entropy (Basel)
Sun QM, Yu QC, Ba D, Du Y.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multistructural and Multiscale Instability Characterization of Gas-Liquid Two-Phase Flow with MRA-CMESSE. [PDF]

Entropy (Basel)
Sun QM, Yu QC, Ba D.
europepmc   +1 more source

A New Contactless Cross-Correlation Velocity Measurement System for Gas-Liquid Two-Phase Flow. [PDF]

Sensors (Basel), 2023
Sheng B, Huang J, Ji H, Huang Z.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanism study of low-ambient-pressure effects on the efficiency of cavitation erosion mitigation by air bubbles in gas-liquid two-phase flow. [PDF]

Ultrason Sonochem
Qu T, Luo J, Li J, Fu G, Yang H, Xu W.
europepmc   +1 more source

Dual-Modal Electrical Imaging of Two-Phase Flow-Experimental Evaluation of the State Estimation Approach. [PDF]

Sensors (Basel), 2023
Arif MZ, Seppänen A, Kolehmainen V, Vauhkonen M.   +3 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of branch roadways on dynamic disaster-causing and energy dissipation characteristics of outburst gas-solid two-phase flow. [PDF]

Sci Rep
Cheng L, Yang H, Xu J, Li S, Shuang H, Hu B, Yang Z.   +6 more
europepmc   +1 more source