Results 71 to 80 of about 1,212,846 (264)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Improvement of Battery Life and Energy Economy for Electric Vehicles with Two-Speed Transmission
Energies, 2020 With the current energy environment background and development of the electrification of the automotive industry, a comprehensive economic indicator, in which the battery aging is further considered on the basis of conventional energy consumption, is ...
Ying Lyu +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
High-speed volumetric two-photon fluorescence imaging of neurovascular dynamics
Nature Communications, 2020 Monitoring hemodynamics in the brain is important in understanding medical imaging data and mechanisms of disease. Here the authors use high-throughput two-photon microscopy with an axially-extended Bessel focus to measure vessel size and blood flow down
Jiang Lan Fan +6 more
doaj +1 more source
Architectural Theory at Two Speeds
Ardeth, 2017 The article is a presentation of the ethnographic method applied to architecture. The author explains how “slow ethnographers” work when they deal with a building, by focusing on the case of namBa HIPS building by Shin Takamatsu, in Osaka. “Slow” ethnography offers an alternative to “quick theory” intended as a critical theory of architecture that is ...
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Two-Speed Romania: An Analysis of Regional Competitiveness Patterns
Studies in Business and EconomicsThis study examines the regional competitiveness of Romanian NUTS 2 regions from 2016 to 2022, employing the EU Regional Competitiveness Index (RCI) 2.0.
Tudose George +4 more
doaj +1 more source
Two-speed genome evolution drives pathogenicity in fungal pathogens of animals. [PDF]
Proc Natl Acad Sci U S A, 2023 Wacker T +5 more
europepmc +1 more source