Results 41 to 50 of about 165,147 (263)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
What Role Does Religion Have in Shaping Human Consumption?
Religions, 2021 Religious belief, as an informal social institution, has a significant impact on all aspects of human civilization. Previous literature has studied the effects of religious belief on economic growth, income, education, etc.
Yugang He, Yinhui Wang, Xiaodan Gao
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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GIScience & Remote SensingWhile the negative health consequences of air pollution exposure are well documented, its effects on economic activities remain less understood. Existing empirical studies often focus on the impacts of air pollution on production-related economic ...
Han-Su Zhang +7 more
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Convex Combination of Ordinary Least Squares and Two-stage Least Squares Estimators
, 2015 In the presence of confounders, the ordinary least squares (OLS) estimator is known to be biased. This problem can be remedied by using the two-stage least squares (TSLS) estimator, based on the availability of valid instrumental variables (IVs). This reduction in bias, however, is offset by an increase in variance.
Ginestet, Cedric E. +2 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
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Computer Sciences & Mathematics ForumTwo-stage least squares (2SLS) regression undergirds much of contemporary geospatial econometrics. Walk-forward validation in time-series forecasting constitutes a special instance of iterative local regression.
James Ming Chen +2 more
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Two-stage least squares as minimum distance [PDF]
The Econometrics Journal, 2019 SummaryThe two-stage least-squares (2SLS) instrumental-variables (IV) estimator for the parameters in linear models with a single endogenous variable is shown to be identical to an optimal minimum-distance (MD) estimator based on the individual instrument-specific IV estimators.
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source