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The Lancet, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden ...
DiMeglio, Linda A. +2 more
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Neurofibromatosis Type 1☆ [PDF]
Journal of the American Academy of Dermatology, 2009 Neurofibromatosis type 1 (NF1) is an autosomal dominant, multisystem disorder affecting approximately 1 in 3500 people. Significant advances in the understanding of the pathophysiology of NF1 have been made in the last decade. While no medical therapies for NF1 are currently available, trials are ongoing to discover and test medical treatments for the ...
A. Theos, B.R. Korf
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Frontiers in Endocrinology, 2023 ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup +10 more
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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Non-Coding RNA, 2022 Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur +9 more
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TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A
Scientific Reports, 2021 TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission after the
Kathrin Koedderitzsch +4 more
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Scientific Reports, 2022 Rheumatoid arthritis (RA) is characterized by joint infiltration of immune cells and synovial inflammation which leads to progressive disability. Current treatments improve the disease outcome, but the unmet medical need is still high.
Lingzi Li +10 more
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The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
Mark A, Atkinson +2 more
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Neurofibromatosis type 1 [PDF]
QJM: An International Journal of Medicine, 2018 The neurofibromatoses are a group of three heterogeneous disorders that include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis. NF1 is the most common of these three conditions, and represents one of the most frequently diagnosed cancer predisposition disorders involving the nervous system.
Patrick J, Cimino, David H, Gutmann
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Introduction: Beauty and nature
Mètode Science Studies Journal: Annual Review, 2023 In a world where it seems best to go unnoticed, many creatures display their beauty in plain sight. We could even say that we are surrounded by beauty. A diverse and overwhelming beauty that inspires artists and engineers, one that scientists have tried (
Raquel Ortells Bañeres +1 more
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Sex and design in our evolutionary cousins: The perception of beauty in nature
Mètode Science Studies Journal: Annual Review, 2023 Taking an evolutionary approach to the question of beauty, we discuss the expression and perception of sexual beauty across the animal kingdom. Animals experience beauty in their brains, and animal brains are tuned to features of the environment most ...
Tamra C. Mendelson, Michael J. Ryan
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