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Frontiers in Endocrinology, 2023 ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup +10 more
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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Non-Coding RNA, 2022 Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur +9 more
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TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A
Scientific Reports, 2021 TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission after the
Kathrin Koedderitzsch +4 more
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Scientific Reports, 2022 Rheumatoid arthritis (RA) is characterized by joint infiltration of immune cells and synovial inflammation which leads to progressive disability. Current treatments improve the disease outcome, but the unmet medical need is still high.
Lingzi Li +10 more
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Introduction: Beauty and nature
Mètode Science Studies Journal: Annual Review, 2023 In a world where it seems best to go unnoticed, many creatures display their beauty in plain sight. We could even say that we are surrounded by beauty. A diverse and overwhelming beauty that inspires artists and engineers, one that scientists have tried (
Raquel Ortells Bañeres +1 more
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Sex and design in our evolutionary cousins: The perception of beauty in nature
Mètode Science Studies Journal: Annual Review, 2023 Taking an evolutionary approach to the question of beauty, we discuss the expression and perception of sexual beauty across the animal kingdom. Animals experience beauty in their brains, and animal brains are tuned to features of the environment most ...
Tamra C. Mendelson, Michael J. Ryan
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BMJ Open, 2023 Objectives Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD.
Bruce H R Wolffenbuttel +4 more
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Belleza y elección de pareja: Lo que la biología evolutiva nos enseña
Mètode Science Studies Journal: Annual Review, 2023 Tendemos a considerar la belleza como el producto destilado de nuestra educación, la quintaesencia de nuestro refinamiento cultural. Además, a menudo destacamos el relativismo de la belleza.
Enrique Font, Enrique V. Font‐Ferrer
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
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Public engagement as rhetoric, persuasion as practice
Mètode Science Studies Journal: Annual Review, 2023 More than two decades ago the Public Engagement with Science and Technology (PEST) paradigm gained influence in the field of science communication, marked by the publication of the third report of the House of Lords Select Committee on Science and ...
Hans Peter Peters
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