Results 121 to 130 of about 37,382,072 (281)

Why Type 1 errors are more important than Type 2 errors (if you care about evidence)

, 2016
After performing a study, you can correctly conclude there is an effect or not, but you can also incorrectly conclude there is an effect (a false positive, alpha, or Type 1 error) or incorrectly conclude there is no effect (a false negative, beta, or Type 2 error). The goal of collecting data is to provide <i> evidence </i> for or against a
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Beyond the traditional simulation design for evaluating type 1 error control: From the "theoretical" null to "empirical" null. [PDF]

Genet Epidemiol, 2019
Zhang T, Sun L.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Multiplicity adjustment approaches in publicly funded multi-arm trials: a comprehensive review of the National Institute for Health and Care Research (NIHR) Journals Library

Trials
Background Parallel-group multi-arm trials are randomised controlled trials (RCTs) where participants are allocated to three or more concurrent treatment groups.
Ellen C. Lee, Richard M. Jacques, Rebecca M. Simpson, Stephen J. Walters   +3 more
doaj   +1 more source

Error report for Wessel (2018)

DECISION AND RECOMMENDATION Wessel (2018) “Prepotent motor activity and inhibitory control demands in different variants of the go/no-go paradigm” was determined to contain Minor Errors. That is, errors that have the benefit of being detectable thanks to
ERROR
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Controlling type 1 error rates in genome-wide association studies in plants. [PDF]

Heredity (Edinb), 2013
George AW.
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source