Results 201 to 210 of about 119,720,646 (296)

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba   +4 more
wiley   +1 more source

Therapeutic Balloon‐Assisted Enteroscopy: Recent Advances in the Management of Small Bowel Diseases

open access: yesDEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Balloon‐assisted enteroscopy (BAE) has substantially advanced small bowel disease management. This review summarizes recent therapeutic BAE advances, focusing on three major indications: small bowel vascular lesions, hereditary polyposis syndromes, and Crohn's disease (CD).
Manabu Nagayama   +8 more
wiley   +1 more source

MEK1/2 Signalling establishes an alloreactive effector T cell program through SMAD4 during cardiac allograft rejection

open access: yesClinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Upon T cell receptor (TCR) engagement by alloantigens, MEK1/2–ERK1/2 signalling promotes SMAD4 nuclear translocation and supports SMAD4‐dependent transcription of effector genes, including Ifng, Tnf, and Il2ra. This transcriptional program promotes alloreactive T cell effector function and contributes to cardiac allograft rejection.
Jiulu Zhao   +8 more
wiley   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

open access: yesFood Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan   +4 more
wiley   +1 more source

Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report

open access: yesIJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Malignant transformation of endometriosis is rare and most commonly involves the ovary; transformation from paraurethral endometriosis is exceedingly rare. Case Presentation A 73‐year‐old postmenopausal woman with prior ovarian endometrioma presented with dysuria and voiding difficulty.
Keita Ogasawara   +9 more
wiley   +1 more source

An Ascorbic‐Acid Containing Poly(Carbonate) Urethane With Antioxidant Bioactivity for Application in Heart Valve Scaffold Development

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Prosthetic heart valve development consists of several branching, innovative strategies to mediate the complex native environment that wears down valve durability. Anti‐calcification treatments are being applied to pericardial tissue, durable polymers are being developed that mitigate oxidative degradation and stress cracking, and heart valve ...
Drake D. Pedersen   +12 more
wiley   +1 more source

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