Results 231 to 240 of about 119,720,646 (296)

Hypoxia‐Driven CA2 Promotes Trophoblast Dysfunction in Preeclampsia

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
CA2 is upregulated in preeclampsia and impairs trophoblast function by suppressing VEGFA under hypoxia/HIF‐1α signaling. LNP‐mediated CA2 silencing improves placental structure and fetal outcomes, highlighting CA2 as a promising therapeutic target for PE.
Lujiao Chen   +7 more
wiley   +1 more source

FAM3A Inhibits Plasma Triglyceride Levels via Microvasculature‐Involved Enhancement of VLDL‐Triglyceride Hydrolysis and Lipid Uptake

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
FAM3A enhances the PPARα signaling, leading to upregulated expression of lipid transporters including CD36 and TCF15. The upregulated CD36 and TCF15 enhance FA uptake and trans‐endothelial delivery in MVECs. Meanwhile, FAM3A‐enhanced PPARα signaling also increases LPL expression in myocytes and LPL position in lumen side of microvasculature to promote ...
Xiaohong Song   +7 more
wiley   +1 more source

Endothelial Matrin‐3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis

open access: yesThe FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Endothelial Matrin‐3 suppresses cellular senescence and protects against atherosclerosis. Matrin‐3 deficiency induces endothelial senescence, mitochondrial dysfunction, and activation of p53‐, cell cycle‐, and senescence‐related pathways. In atherosclerosis‐prone mice, endothelial Matrin‐3 deletion promotes atherosclerotic lesion formation and disrupts
Xiao Cheng   +5 more
wiley   +1 more source

Apixaban removal during emergency surgery for type A acute aortic dissection: a prospective cohort study. [PDF]

open access: yesInt J Surg
Røed-Undlien H   +9 more
europepmc   +1 more source

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