Results 41 to 50 of about 18,426,765 (306)

Aortic Dissection that Presented to a Tertiary Hospital's ED in Dubai, UAE: A Descriptive Study

Saudi Journal of Emergency Medicine
Background: Aortic dissection is a life-threatening condition, with a high mortality rate. It can be classified into Stanford type A or type B. This study analyzes the clinical presentation, risk factors, systolic blood pressure, and the mortality rate ...
Ivyan Kambal, Esra AlHamadani, Rand Aboelkher, Sania Zia, Firas AlNajjar   +4 more
doaj   +1 more source

The Many Lives of a Complex Marfan Syndrome Patient

JACC: Case Reports, 2021
We present a complex Marfan case, with previous type A aortic dissection, subsequent progressing aortic arch aneurysm, type B chronic aortic dissection, and Barlow disease with severe mitral regurgitation, all expressions of the same phenotype, all ...
Cristian Militaru, MD, PhD, Horaţiu Moldovan, MD, PhD, Bogdana Fetecău, MD, Bogdan A. Popescu, MD, PhD, Miklos Pólos, MD, PhD, Zoltan Szabolcs, MD, PhD, Ruxandra Jurcuţ, MD, PhD   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Long‐Term Outcomes of Chronic Type B Aortic Dissection Treated by Thoracic Endovascular Aortic Repair

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The treatment of chronic type B aortic dissection by thoracic endovascular aortic repair has some challenges, and its long‐term outcomes remain unclear.
Xiaolang Jiang, Yifan Liu, Lingwei Zou, Bin Chen, Junhao Jiang, Weiguo Fu, Zhihui Dong   +6 more
doaj   +1 more source

Stenting of the aortic arch as an emergency palliation of aortic dissection after cardiac surgery in an infant [PDF]

, 2005
Aortic dissection with low cardiac output is an acute emergency and immediate therapy is mandatory. It is however a disease of the elderly. This article reports on an infant who developed acute aortic dissection following cardiac surgery, for whom ...
Emmel, Matthias Alexander, Brockmeier, Konrad, Sreeram, Narayanswami   +2 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Arc of Buhler: A lifesaving anatomic variation. A case report [PDF]

Jornal Vascular Brasileiro, 2020
The presence of malperfusion syndrome in cases of complicated acute type B aortic dissection is a negative predictive factor and urgent intervention is indicated.
Schizas Nikolaos, Patris Vasilios, Lama Niki, Eleftherios Orestis Argyriou, Kratimenos Theodoros, Argiriou Mihalis   +5 more
doaj   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Outcome of Stanford type B dissection in patients with Marfan syndrome. [PDF]

, 2023
OBJECTIVE To determine the outcome of Stanford type B aortic dissection in patients with Marfan syndrome and to evaluate aortic diameters at time of dissection as well as the impact of previous aortic root replacement.
Nucera, Maria, Becker, Daniel, Silvan Jungi, Yildiz, Murat, Jungi, Silvan, Maria Nucera, Florian Schoenhoff, Selim Mosbahi, Mosbahi, Selim, Matthias Siepe, Siepe, Matthias, Schoenhoff, Florian, Paul Philipp Heinisch, Heinisch, Paul Philipp, Murat Yildiz, Daniel Becker   +15 more
core   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source