Results 31 to 40 of about 16,178,355 (360)

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Panke, Sven, Heinemann, Matthias,, Panke, Sven,, Heinemann, Matthias   +3 more
core   +1 more source

Variation in some characters of the genus Sceliphron (Hymenoptera: Sphecidae) in the Philippines

Journal of Asia-Pacific Biodiversity, 2020
The observed morphological and color variations for Sceliphron species in the Philippines are hereby reported. Sceliphron madraspatanum conspicillatum and Sceliphron rufopictum laticinctum have several variations in propodeal maculation pattern and in ...
Kristine O. Abenis, Ireneo L. Lit, Jr., Byeong-Tae Choi, Doo-Sang Park   +3 more
doaj   +1 more source

Structure and Biology of Type VIII Collagen.

Trends in Glycoscience and Glycotechnology, 1992
VIII型コラーゲンは、ウシ大動脈内皮細胞の培養系における生合成産物として最初に報告されたので、従来は内皮細胞コラーゲン (EC) と呼ばれていた。このタンパク質は現在、トリおよび哺乳類のケラチノサイト、線維芽細胞、星状細胞腫や他の腫瘍細胞、さらに様々な大きさの血管に由来する内皮細胞などによって分泌されることが知られている。生体内ではVIII型コラーゲンの分布は限られており、例えば髄膜、骨膜、軟骨膜、角膜のデスメ膜などの細胞外マトリックスに存在する。また大小血管の内皮下層や内皮細胞の発芽培養系で形成される毛細血管様構造にも存在する。タンパク質のアミノ酸配列と核酸塩基配列から、VIII型コラーゲンはα1 (VIII) およびα2 (VIII ...
Iruela-Arispe, M Luisa, Chun, Lawrence E, Sage, E Helene   +2 more
openaire   +4 more sources

m6A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes

Nature Metabolism, 2019
The regulation of islet cell biology is critical for glucose homeostasis1. N6-methyladenosine (m6A) is the most abundant internal messenger RNA (mRNA) modification in mammals2. Here, we report that the m6A landscape segregates human type 2 diabetes (T2D)
Dario F. De Jesus, Zijie Zhang, S. Kahraman, Natalie K Brown, Mengjie Chen, Jiang Hu, Manoj K. Gupta, Chuan He, R. Kulkarni   +8 more
semanticscholar   +1 more source

Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology [PDF]

, 2009
The use of computational modeling and simulation has increased in many biological fields, but despite their potential these techniques are only marginally applied in nutritional sciences.
Ommen, Ben van, De Roos Baukje, Ommen, Ben van,, van Ommen Ben, van Ommen, Ben, Graaf, A.A. de, Martin Adiels, Adiels, Martin,, Rullmann, Johan A.C., Roos, Baukje de, Kevin D. Hall, de Graaf Albert A., Freidig, Andreas P.,, Hall, Kevin D.,, Neema Jamshidi, Andreas P. Freidig, Adiels, M., Hall, Kevin D, Hall Kevin D., Baukje De Roos, Johan A C Rullmann, Rullmann, J.A.C., Ben van Ommen, Graaf, Albert A. de, Rullmann Johan A.C., Freidig, Andreas P, Andreas P Freidig, Jamshidi Neema, Jamsheedi, Neema, Heinemann, M., Heinemann Matthias, Roos, B. de, Johan A.C. Rullmann, Adiels Martin, De Roos, Baukje, Ommen, B. van, Albert A de Graaf, Jamshidi, Neema,, de Graaf, Albert A, Adiels, Martin, Hall, K.D., Freidig, Andreas P., Heinemann, Matthias,, Hall, Kevin D., Roos, Baukje de,, Rullmann, Johan A C, Heinemann, Matthias; id_orcid, Albert A. de Graaf, Freidig Andreas P., Rullmann, Johan AC, Graaf, Albert A. de,, Freidig, A.P., Heinemann, Matthias, Matthias Heinemann, Rullmann, Johan A.C.,, Jamshidi, Neema, Jamshidi, N., Kevin D Hall   +57 more
core   +1 more source

The structural biology of type IV secretion systems [PDF]

Nature Reviews Microbiology, 2009
Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein-protein and protein-DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes.
Rémi, Fronzes, Peter J, Christie, Gabriel, Waksman   +2 more
openaire   +2 more sources

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Frontiers in Immunology, 2021
Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr, Isabelle Serr, Felix Drost, Benjamin Schubert, Benjamin Schubert, Carolin Daniel, Carolin Daniel, Carolin Daniel   +7 more
doaj   +1 more source

Structural biology of type VI secretion systems [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2012
Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria–host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific ...
Cascales, E., Cambillau, Christian
openaire   +5 more sources

Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease

Wiley Interdisciplinary Reviews: Developmental Biology, 2016
Skeletal muscle fibers are classified into fiber types, in particular, slow twitch versus fast twitch. Muscle fiber types are generally defined by the particular myosin heavy chain isoforms that they express, but many other components contribute to a ...
Jared C. Talbot, L. Maves
semanticscholar   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities [PDF]

Information Fusion, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include myriad properties describing genome, epigenome, transcriptome, microbiome, phenotype, and lifestyle.
M. Zitnik, Francis Nguyen, Bo Wang, J. Leskovec, A. Goldenberg, M. M. Hoffman   +5 more
semanticscholar   +1 more source