Results 111 to 120 of about 3,278,641 (315)

Optimal Design of Reverse-six-link Mechanism of Type ZL50 Loader

Jixie chuandong, 2018
In consideration of the effect of the work stroke of lifting cylinder and bucket cylinder on the working performance of loader,the work strokes of the two cylinders are then selected to be design variables together with the position coordinates of the ...
Chen Xinde
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Jan Tschichold, ‘La forma del libro’, Vicenza, Ronzani Editore, 2022

TECA
Chiara Reatti
doaj   +1 more source

Design of a Composite Type Three-phase AC Output Busbar

Kongzhi Yu Xinxi Jishu, 2017
High compactness, low stray inductance and high power density are required in electric locomotive converter wiring, while the traditional cable and single-layer conductive copper are often difficult to meet the requirements.
ZHANG Yu
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Design and Analysis of Double Crank Type Climbing Mechanism

Jixie chuandong, 2019
Through the comparative analysis of the climbing mechanism of stair climbing wheelchair， a double crank type climbing mechanism is proposed. The design and research of the double crank type climbing mechanism is studied， and the kinematics model of the ...
Zhanli Li Shuang Chen Yanwei Ji Chuntian Lu Guanhong Wang
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Design of Axle Sleeve Type Spline of Gauge-changeable Wheelset

机车电传动, 2018
The function, structure and material selection of axle sleeve type spline were introduced, and the strength calculation of involute tooth of spline was carried out.
HUANG Zhihui, XIA Chaoguo, HU Feifei, DAI Xiaochao   +3 more
doaj  

Optimal design of dual magnetic float type level gauge to detect a specific level

, 2008
Dong-Sok Kim, Jae-Man Han, Soo‐Gil Park   +2 more
openalex   +2 more sources

A new approach to HLA typing designed for solid organ transplantation: epityping and its application to the HLA‐A locus [PDF]

, 2013
Emma Lougee, Sejal Morjaria, Olivia Shaw, R. W. Collins, R. S. Vaughan   +4 more
openalex   +1 more source