Results 171 to 180 of about 31,306,322 (385)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Improved Design of Interlocking Device of KYN44-12 Type Switchgear

open access: yesGong-kuang zidonghua, 2012
The paper introduced design principle of interlocking device of 12 kV switchgear, analyzed existing problems and shortcomings of the interlocking device of switchgear in actual operation, and put forward improved and perfect design method of the ...
ZHANG Hong-guang, WANG Ling
doaj  

Effective design and simulation of surface-based lattice structures featuring volume fraction and cell type grading

open access: yesMaterials & Design (1980-2015), 2018
I. Maskery   +5 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee   +9 more
wiley   +1 more source

Design of Grounding Protection for Straddle Type Monorail Car

open access: yes机车电传动, 2018
There are many kinds of grounding protection circuits for urban rail transit in China. Taking the design of Chongqing straddle monorail and power supply system as an example, the design, protection principle and protective coordination relationship of ...
WANG Long   +3 more
doaj  

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